NUCB2/Nesfatin-1 在DIO大鼠下丘脑中的表达

doi:10.13418/j.issn.1001-165x.2014

Abstract

Abstract:

Objective　To explore the NUCB2/Nesfatin-1 expression level in hypothalamus of diet induced obesity（DIO）rats, and to provide experimental basis for the mechanism of nerve regulation by glucolipid metabolism.　Methods　To setting up high glucose and lipid rat model by high-energy feed, using immunohistochemical method to detect the hypothalamus NUCB2/Nesfatin-1 expression level. 　Results　（1）NUCB2/Nesfatin-1 expression positive rate was 43.33% in the hypothalamus of the experimental group, which was significantly lower than that（80.00%）in the control group（P<0.05）.（2）NUCB2/Nesfatin-1 expression strength score was 2.159±0.918 in the hypothalamus in the experimental group, and was 3.683±1.250 in the control group（P<0.01）.　Conclusion 　NUCB2/Nesfatin-1 expression level was decreased obviously in the hypothalamus of diet induced obesity rats，suggesting NUCB2/Nesfatin-1 may play an important role in regulating glucolipid metabolism.

Key words: Nucleobindin-2/nucleobindin2-encoded satiety-and-fat-influenc- ing protein-1, Glucolipid metabolism, Hypothalamus

CLC Number:

R338.27

QIN Xiao-Yun, WANG Ba-Jun, WU Shan-An, ZHANG Qiang-Jin, LIU Man-Jun, LAN Ling-Yuan, ZHANG Meng-Ya, HUANG Bei, QIN Xiao-Hua, JIA Chun-Bei. NUCB2/Nesfatin-1expression in the hypothalamus of DIO rats[J]. Chinese Journal Of Clinical Anatomy, 2014, 32(6): 704-707.

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NUCB2/Nesfatin-1expression in the hypothalamus of DIO rats

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