颈内动脉狭窄对大脑动脉环血流动力学影响的有限元分析

doi:10.13418/j.issn.1001-165x.2016.06.015

中国临床解剖学杂志 ›› 2016, Vol. 34 ›› Issue (6): 672-676.doi: 10.13418/j.issn.1001-165x.2016.06.015

颈内动脉狭窄对大脑动脉环血流动力学影响的有限元分析

林蔚莘¹，　周毅强¹，　黄学成²，　李义凯³

1.厦门市中医院骨三科，福建厦门 361000； 2.广州中医院大学第一临床医学院，广州 510009；
3.南方医科大学中医药学院，广州 510515

收稿日期:2016-09-11 出版日期:2016-11-25 发布日期:2016-12-20
作者简介:林蔚莘（1982-），男，福建安溪人，主治医师，博士，主要从事骨科临床解剖学及生物力学方面的研究，Tel：（0592）5579722，E-mail：wessen@163.com
基金资助:
国家自然科学基金( 81273871)

Hemodynaic of cerebral arterial circle affected by stenosis in ICA: A finite element analysis

LIN Wei-shen¹, ZHOU Yi-qiang¹, HUANG Xue-cheng², LI Yi-kai³

1. Department of Orthopaedics, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian 361000, China; 2. First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510009, China; 3.Academy of Traditional Chinese Medicine, Southern Medical University, Guangdong Province, Guangzhou 510515, China

Received:2016-09-11 Online:2016-11-25 Published:2016-12-20

摘要/Abstract

摘要：

目的　大脑动脉环血流变化常与颈内动脉狭窄相联系。本研究试用有限元方法来研究颈内动脉狭窄对大脑动脉环内的血流动力学影响，以此探讨动脉环内交通动脉代偿机制。方法　采用MIMICS10.0软件及ANSYS14.5软件，建立了一个包括血管和血流在内的流固耦合的三维有限元模型，模拟了健康模型（颈内动脉无狭窄）及各种病理模型（颈内动脉狭窄率分别为15%、 30%、 45%, 60%、 70%、 80% 和90%）。通过监测前交通动脉和后交通动脉内的血流变化，掌握动脉环内血流动力学的改变。结果　包括血管和血流的流固耦合有限元模型首次得以建立。随着狭窄率增加，前交通动脉与患侧后交通动脉内血流逐渐增多，狭窄率达到90%后，两条血管内血流减少；健侧后交通动脉内血流也全程逐渐增加，但量极小，基本无明显变化。结论　通过以上的结果可见，随着颈内动脉狭窄程度的加重，大脑动脉环通过前交通动脉与患侧后交通动脉开放达到代偿，狭窄率达到90%后代偿失效，从机制上印证了颈内动脉狭窄与颅内缺血性病变相关。

关键词: 大脑动脉环, 颈内动脉狭窄, 有限元

Abstract:

Objective　The cerebral arterial circle is usually associated with the internal carotid artery (ICA) stenosis. The finite element method was used to analyze the influence of stenosis on the hemodynamics in the circle and find out the compensatory mechanism of communicating arteries.　Methods A fluid-solid coupling 3D finite element model was created using MIMICS10.0 and ANSYS14.5. The healthy and the diseased (ratios of stenosis include 15%, 30%, 45%, 60%, 70%, 80%, and 90%) situations were simulated. Blood flow was then monitored at the communicating arteries (ACoA,PCoA).　Results　A fluid-solid coupling 3D finite element model including blood and vessels was created for the first time. Blood flow in ACoA and the right PCoA increased according to the increase of stenosis ratio, but decreased when the stenosis ratio was up to 90%. Blood flow in the left PCoA increased slightly through the whole course. Conclusion　The ACoA and PCoA of affected side open gradually to compensate the loss of blood according to the increasing of stenosis ration, and decompensate when the rate was up to 90%. Stenosis in the internal carotid was proved mechanical associate with intracranial ischemic disease.

Key words: Cerebral arterial circle, Carotid Stenosis, Finite Element Analysis

林蔚莘,周毅强,黄学成,李义凯. 颈内动脉狭窄对大脑动脉环血流动力学影响的有限元分析[J]. 中国临床解剖学杂志, 2016, 34(6): 672-676.

LIN Wei-shen, ZHOU Yi-qiang, HUANG Xue-cheng, LI Yi-kai. Hemodynaic of cerebral arterial circle affected by stenosis in ICA: A finite element analysis[J]. Chinese Journal Of Clinical Anatomy, 2016, 34(6): 672-676.

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颈内动脉狭窄对大脑动脉环血流动力学影响的有限元分析

Hemodynaic of cerebral arterial circle affected by stenosis in ICA: A finite element analysis

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