关键词: 结节, 　CT, 　病理, 　临床

Abstract:

Objective　 To explore pathological features of solid and subsolid nodules and identify the radiological characteristic differences between them.　Methods　A total of 804 patients with solitary pulmonary nodules (SPNs) were studied retrospectively following surgical resection treatment with a definite postoperative pathology. The SPNs were classified as either solid or subsolid nodules depending on the presence of ground-glass lesion based on thoracic CT scan results. Pathological causes of SPNs were also evaluated and compared between solid and subsolid nodule groups. Demographic (gender and age) and clinical data (smoking and cancer history, the maximum diameter and location of lung nodule) were retrieved to determine difference between solid and subsolid nodules.　Results　Of the 804 SPN patients, 393 (48.9%) cases were identified as benign SPNs and 411 (51.1%) as malignant, while 544 (67.7%) cases were solid nodules and 260 (32.3%) subsolid nodules. In solid nodules group, 333 (61.2%) cases were diagnosed as benign and 211 (38.8%) cases as malignant. In the subsolid nodules group, 60 (23.1%) cases were benign and 200 (76.9%) cases malignant. The proportion of benign lesions in solid nodules was significantly higher than those in subsolid nodules (P<0.001). In addition, there were significant differences in the subtypes of adenocarcinoma between solid and subsolid nodules (P<0.001). The ratios of female patients, nonsmokers and upper lobe locations were much higher in subsolid nodules than solid nodules.   Conclusion   Lung adenocarcinoma related subsolid nodules but not the solid nodules are more inclined to be developed in female and non-smokers (passive smoker) than male and smokers. In most cases, the nodules are found to be presented in upper lobe of the human lungs.

Key words: Nodule, 　CT, 　 Pathology, 　Clinical