目的　探讨使用解痉药物预防去甲肾上腺素诱发的血管痉挛。  方法　64只SD大鼠随机分为8组，在其股动静脉区域滴加7种解痉挛药剂预处理30 min（前列腺素E1、硝普钠、硫酸镁、罂粟碱、酚妥拉明、维拉帕米和利多卡因），生理盐水作为对照组。随后分别滴加去甲肾上腺素0.1 ml（1:1000），建立血管痉挛模型。通过激光散斑血流成像系统监测股动静脉灌注强度和内径，数据处理为血流灌注。采用单因素方差分析进行组间股血管灌注差异比较。  结果　对照组（生理盐水）局部应用去甲肾上腺素5 min，动脉灌注约降低91%，静脉灌注约降低78%。硝普钠和酚妥拉明组均可预防股动静脉血管痉挛（P<0.05），罂粟碱仅对股动脉痉挛有预防作用，前列腺素E1仅对股静脉有预防痉挛的作用。  结论　术前使用硝普钠和酚妥拉明预处理血管，可以预防去甲肾上腺素诱发的动静脉痉挛。其中硝普钠预防效果最强，酚妥拉明效果次之。

Objective　To explore the use of antispasmodic drugs to prevent norepinephrine- induced vasospasm. 　Methods　Sixty-four SD rats were randomly divided into 8 groups. The rats were pretreated with 7 kinds of antispasmodic drugs for 30 minutes（Prostaglandin E1, sodium nitroprusside, magnesium sulfate, papaverine, phentolamine, verapamil and lidocainehydrocloride). Normal saline was used as a control agent. Then 0.1 ml norepinephrine (1:1000) was added to trigger vasospasm. The perfusion intensity and diameter of the femoral artery and vein were monitored by a laser speckle blood flow imaging system. Spss19.0 was used to compare the perfusion difference between groups.　Results　In the control group (normal saline), local application of norepinephrine for 5 minutes reduced arterial perfusion by 91% and venous perfusion by 78%. Both sodium nitroprusside and phentolamine could prevent the vasospasm of femoral artery and vein (P<0.05); papaverine only prevented the spasm of the femoral artery, and prostaglandin E1 only prevented the spasm of the femoral vein.　Conclusions　Pretreatment with sodium nitroprusside and phentolamine can prevent norepinephrine-induced vasospasm. Sodium nitroprusside has the strongest preventive effect, followed by phentolamine.