等离子射频消融术治疗老年早期声门型喉癌的远期疗效及其对嗓音声学影响

doi:10.13418/j.issn.1001-165x.2022.2.18

中国临床解剖学杂志 ›› 2022, Vol. 40 ›› Issue (2): 216-220.doi: 10.13418/j.issn.1001-165x.2022.2.18

等离子射频消融术治疗老年早期声门型喉癌的远期疗效及其对嗓音声学影响

台勇¹，　吉昱姿¹，　马季青¹*，　臧艳姿¹，　刘飞¹，　徐定远¹，　裴莹莹¹，　郝慧娟²

1.河南省人民医院耳鼻咽喉头颈外科，郑州 450003；　2.新郑市人民医院耳鼻喉科，河南新郑 451100

收稿日期:2020-01-29 出版日期:2022-03-25 发布日期:2022-04-12
通讯作者: 马季青，主治医师，E-mail：taiyongyxy@126.com
作者简介:台勇（1983-），男，河南郑州人，硕士，主治医师，主要从事咽喉头颈肿瘤的防治，E-mail：taiyongyxy@126.com
基金资助:
河南省科技攻关计划项目（172102310035）

Long-term effect of radiofrequency ablation in the treatment of early glottic cancer in the elderly and its effect on voice acoustics

Tai Yong¹， Ji Yuzi¹， Ma Jiqing¹*， Zang Yanzi¹，Liu Fei¹， Xu Dingyuan¹，Pei Yingying¹， Hao Huijuan²

1. Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China; 2. Department of Otorhinolaryngology, People's Hospital of Xinzheng, Xinzheng 451100, Henan Province, China

Received:2020-01-29 Online:2022-03-25 Published:2022-04-12

摘要/Abstract

摘要： 目的　探究等离子射频消融术治疗老年早期声门型喉癌（early glottic cancer，EGC）的远期疗效及其对嗓音声学的影响。方法回顾性分析2010年5月~2011年5月河南省人民医院耳鼻咽喉头颈外科收治的95例EGC患者临床资料，根据治疗方案的不同将其分为研究组和对照组，对照组46例行CO2激光切除术，研究组49例行等离子射频消融术治疗，比较两组视觉模拟评分（visual analogue scale，VAS）、临床疗效总有效率、嗓音学指标（基频微扰、标准化噪声能量、振幅微扰）、术后生活质量（躯体疼痛、生理功能、生理职能、总体健康评分）及远期疗效（5年生存率、局部复发率）。结果 VAS评分研究组较对照组无统计学差异（P>0.05）；总有效率研究组高于对照组（P<0.05）；术后6个月嗓音学指标研究组低于对照组（P<0.05）；术后生活质量评分研究组略高于对照组，差异无统计学意义（P>0.05）；5年生存率、局部复发率研究组较对照组无统计学差异（P>0.05）。结论等离子射频消融术治疗老年早期声门型喉癌临床疗效较好，具有嗓音恢复快、术后疼痛感轻的优势，值得临床推广应用。

关键词: 等离子射频消融术, 　早期声门型喉癌, 　远期疗效, 　嗓音声学

Abstract: Objective　To investigate the long-term effect of radiofrequency ablation in the treatment of early glottic cancer (EGC) in the elderly and its effect on voice acoustics.　Methods　The clinical data of 95 patients with EGC admitted to our hospital from May 2010 to May 2011 were analyzed retrospectively. Patients were divided into two groups according to the different treatment methods. Control group (n=46) received the CO2 laser surgery, and study group (n=49) received the radiofrequency ablation. Then various indexes were compared between groups, including operation time, hospitalization time, VAS score, total effective rate, voice acoustics indexes [Jitter, normalized noise energy (NNE), amplitude perturbation (Shimmer)], quality of life (bodily pain, physiological function, general health score), and long-term efficacy (5-year survival rate, local recurrence).　Results　There were no statistical difference in the VAS score between the study group and the control group (P>0.05), and the total effective rate of the study group was significantly higher than that of the control group (P<0.05). Jitter, NNE and Shimmer in the study group were lower than in the control group (P<0.05). The postoperative quality of life scores in the study group were slightly higher than those in the control group, with no statistic difference (P>0.05). There were no statistical difference in 5-year survival rate and local recurrence rate between the two groups(P>0.05).　Conclusions　The application of radiofrequency ablation in the treatment of EGC in the elderly has the advantages of fast voice recovery, which is worthy of clinical promotion.

Key words: Radiofrequency ablation, 　Early glottic cancer, 　Long-term outcome, 　Voice acoustics

中图分类号:

R454.1

台勇, 吉昱姿, 马季青, 臧艳姿, 刘飞, 徐定远, 裴莹莹, 郝慧娟. 等离子射频消融术治疗老年早期声门型喉癌的远期疗效及其对嗓音声学影响[J]. 中国临床解剖学杂志, 2022, 40(2): 216-220.

Tai Yong, Ji Yuzi, Ma Jiqing, Zang Yanzi, Liu Fei, Xu Dingyuan, Pei Yingying, Hao Huijuan. Long-term effect of radiofrequency ablation in the treatment of early glottic cancer in the elderly and its effect on voice acoustics[J]. Chinese Journal of Clinical Anatomy, 2022, 40(2): 216-220.

参考文献 15

[1]	毛扬纯. 低温等离子射频消融术治疗早期声门型喉癌的临床探究[J]. 当代医学, 2017, 11(31): 127-129. DOI: 10.3969/j.issn.1009-4393. 2017. 31.073.
[2]	Chakraborty S, Muttath G. Carotid sparing intensity-modulated radiotherapy in early glottic cancers: a case of Maslow's hammer[J]. J Cancer Res Ther，2015, 11(2): 495-496. DOI: 10.4103/0973-1482.139607.
[3]	Hong CS, Oh D, Ju SG, et al. Carotid-sparing tomoHelical 3-dimensional conformal radiotherapy for early glottic cancer[J]. Cancer Res Treat, 2016, 48(1): 63-70. DOI: 10.4143/crt.2014.265.
[4]	魏云云. 低温等离子刀射频消融治疗早期声门型喉癌临床效果观察[J]. 当代医学, 2018, 480(1): 112-113. DOI: 10.3969/j.issn.1009-4393. 2018.01.052.
[5]	侯彬, 黄维平, 尹中普,等. 低温等离子射频消融术治疗早期声门型喉癌的疗效及影响因素分析[J]. 癌症进展, 2021,19(13): 1345-1348.
[6]	Haymerle G, Fahim T, Heiduschka G, et al. P15 Prognostic markers in early glottic cancer[J]. Oral Oncology, 2015, 51(5): 47-51. DOI: 10.1016/j.oraloncology.2015.02.063.
[7]	Lee M, Buchanan MA, Riffat F, et al. Complications after CO\r, 2\r, laser surgery for early glottic cancer: an institutional experience[J]. Head & Neck, 2016, 38(1): 987-990.
[8]	Watson M, Drosdowsky A, Frowen J, et al. Voice outcomes after radiotherapy treatment for early glottic cancer: long-Term follow-up[J]. J Voice, 2017, 23(6): 2643-2650. DOI: 10.1016/j.jvoice.2017.08.025.
[9]	Truschnegg A, Acham S, Kqiku L, et al. CO2 laser excision of a pyogenic granuloma associated with dental implants: a case report and review of the literature[J]. Photomed Laser Surg, 2016, 34(9):425-431. DOI: 10.1089/pho.2016.4089 .
[10]	戴俊, 怀德, 陈智斌. CO2激光联合低温等离子射频消融术治疗累及前联合早期声门型喉癌临床观察[J]. 中国肿瘤临床与康复, 2017, 10(6): 36-38. DOI: CNKI:SUN:ZGZK.0.2017-06-009.
[11]	王昶. CO2激光治疗早期声门型喉癌后复发的相关因素分析[J]. 中国激光医学杂志, 2018, 9(5): 358-362.
[12]	黄岸坤, 周幸强, 杜宝文. CO2激光喉镜显微手术治疗早期声门型喉癌的疗效分析[J]. 河北医学, 2018, 22(5): 823-826. DOI: 10.3969/j.issn.1006-6233.2018.05.032.
[13]	刘敏, 牛广宪. 低温等离子射频消融术治疗早期声门型喉癌疗效分析[J]. 听力学及言语疾病杂志, 2015, 10(4): 129-133. DOI: 10.3969/j.issn.1006-7299.2015.04.024.
[14]	赵斐斐, 赵琳, 崔晓波, 等. 低温等离子与CO2激光微创治疗早期声门型喉癌疗效及安全性比较[J]. 现代生物医学进展, 2016, 14(36): 7087-7090. DOI: 10.13241/j.cnki.pmb.2016.36.022.
[15]	石栋梁, 杜涛, 习国平. 应用免疫组织化学检测EphA2及其调节基因HoxA1、C-myc在喉癌组织中的表达及相互关系[J]. 河北医科大学学报, 2014, 35(9):1018-1021. DOI: 10.3969/j.issn.1007-3205. 2014. 09. 009.

等离子射频消融术治疗老年早期声门型喉癌的远期疗效及其对嗓音声学影响

Long-term effect of radiofrequency ablation in the treatment of early glottic cancer in the elderly and its effect on voice acoustics

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 15

相关文章 1

Metrics

本文评价

推荐阅读 0