淋巴外科手术治疗阿尔茨海默病的专家共识(2025版)

谢庆平, 王伊龙, 潘伟人, 杨晓东, 郭辉, 肖明, 王海文, 毛之奇, 郑晓菊, 付晓红, 刘军, 熊凌云, 徐志鹏, 陆芸, 袁学谦, 侯建玺, 潘岳松

中国临床解剖学杂志 ›› 2025, Vol. 43 ›› Issue (2) : 121-127.

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中国临床解剖学杂志 ›› 2025, Vol. 43 ›› Issue (2) : 121-127. DOI: 10.13418/j.issn.1001-165x.2025.2.01
专家共识

淋巴外科手术治疗阿尔茨海默病的专家共识(2025版)

  • 谢庆平1,17,    王伊龙2,    潘伟人3,    杨晓东4,    郭辉5,    肖明6,    王海文7,    毛之奇8,    郑晓菊9
    付晓红10,    刘军11,    熊凌云12,    徐志鹏13,    陆芸14,    袁学谦15,    侯建玺16,    潘岳松2

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Expert consensus on lymphatic surgical treatment for Alzheimer's disease(2025 edition)

  • Xie Qingping1,17, Wang Yilong2, Pan Weiren3, Yang Xiaodong4, Guo Hui5, Xiao Ming6, Wang Haiwen7, Mao Zhiqi8, Zheng Xiaoju9, Fu Xiaohong10, Liu Jun11, Xiong Lingyun12, Xu Zhipeng13, Lu Yun14, Yuan Xueqian15, Hou Jianxi16, Pan Yuesong2

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谢庆平, 王伊龙, 潘伟人, 杨晓东, 郭辉, 肖明, 王海文, 毛之奇, 郑晓菊, 付晓红, 刘军, 熊凌云, 徐志鹏, 陆芸, 袁学谦, 侯建玺, 潘岳松. 淋巴外科手术治疗阿尔茨海默病的专家共识(2025版)[J]. 中国临床解剖学杂志. 2025, 43(2): 121-127 https://doi.org/10.13418/j.issn.1001-165x.2025.2.01
Xie Qingping, Wang Yilong, Pan Weiren, Yang Xiaodong, Guo Hui, Xiao Ming, Wang Haiwen, Mao Zhiqi, Zheng Xiaoju, Fu Xiaohong, Liu Jun, Xiong Lingyun, Xu Zhipeng, Lu Yun, Yuan Xueqian, Hou Jianxi, Pan Yuesong. Expert consensus on lymphatic surgical treatment for Alzheimer's disease(2025 edition)[J]. Chinese Journal of Clinical Anatomy. 2025, 43(2): 121-127 https://doi.org/10.13418/j.issn.1001-165x.2025.2.01
中图分类号: R616.2    R653         

参考文献

[1]  卢鸿瑞, 谭云飞, 谢庆平. 3D脱目镜下行颈深淋巴管-静脉引流术治疗老年认知障碍患者一例疗效初步观察[J]. 中华显微外科杂志, 2022, 45(5): 570-574. DOI:10.3760/cma.j.cn441206-20210809-00194.
[2]  Xie Q, Louveau A, Pandey S, et al. Rewiring the brain: the next frontier in supermicrosurgery[J]. Plast Reconstr Surg, 2024, 153(2):494e-495e. DOI: 10.1097/PRS.0000000000010933.
[3]  Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels[J]. Nature, 2015, 523(7560):337-341. DOI: 10.1038/nature14432.
[4]  Wang L, Zhang Y, Zhao Y, et al. Deep cervical lymph nodeligation aggravates AD-like pathology of APP/PS1 mice[J]. Brain Pathol, 2019, 29(2):176-192.  DOI: 10.1111/bpa.12656.
[5]  Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders[J]. Lancet Neurol, 2018, 17(11):1016-1024. DOI: 10.1016/S1474-4422(18)30318-1.
[6] Feng W, Zhang Y, Wang Z, et al. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance[J]. Alzheimers Res Ther, 2020,12(1):125. DOI: 10.1186/s13195-020-00688-1.
[7]  Da Mesquita S, Fu Z, Kipnis J. The meningeal lymphatic system: a new player in neurophysiology[J]. Neuron, 2018, 100(2):375-388. DOI: 10.1016/j.neuron.2018.09.022.
[8]  Hu X, Deng Q, Ma L, et al. Meningeal lymphatic vessels regulate brain tumor drainage and immunity[J]. Cell Res, 2020, 30(3):229-243. DOI: 10.1038/s41422-020-0287-8.
[9] Yamada K, Iwatsubo T. Involvement of the glymphatic/meningeal lymphatic system in Alzheimer's disease: insights into proteostasis and future directions[J]. Cell Mol Life Sci, 2024, 81(1):192. DOI: 10.1007/s00018-024-05225-z.
[10]Salvador AFM, Abduljawad N, Kipnis J. Meningeal lymphatics in central nervous system diseases[J]. Annu Rev Neurosci, 2024, 47(1):323-344. DOI: 10.1146/annurev-neuro-113023-103045.
[11] Chachaj A, Gąsiorowski K, Szuba A, et al.  The lymphatic system in the brain clearance mechanisms - new therapeutic perspectives for Alzheimer's disease[J]. Curr Neuropharmacol, 2023, 21(2):380-391. DOI: 10.2174/1570159X20666220411091332.
[12]Louveau A, Herz J, Alme MN, et al. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature[J]. Nat Neurosci, 2018, 21(10):1380-1391. DOI: 10.1038/s41593-018-0227-9. 
[13] Da Mesquita S, Louveau A, Vaccari A, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease[J]. Nature, 2018, 560(7717):185-191. DOI: 10.1038/s41586-018-0368-8.
[14] Ye C, Wang S, Niu L, Yang F, et al. Unlocking potential of oxytocin: improving intracranial lymphatic drainage for Alzheimer's disease treatment[J]. Theranostics, 2024, 14(11):4331-4351. DOI: 10.7150/thno.98587.
[15] Shan X, Lu Y, Luo Z, et al. A long-acting lyotropic liquid crystalline implant promotes the drainage of macromolecules by brain-related lymphatic system in treating aged Alzheimer's disease[J]. ACS Nano, 2024, 18(13):9688-9703. DOI: 10.1021/acsnano.4c01206.
[16] Wang L, Zhang Y, Zhao Y, et al. Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice[J]. Brain Pathol, 2019, 29(2):176-192 DOI: 10.1111/bpa.12656. 
[17] Hong JP, Chen WF, Nguyen DH, et al. A proposed role for lymphatic supermicrosurgery in the management of Alzheimer's disease: a primer for reconstructive microsurgeons[J]. Arch Plast Surg, 2025,52(2):96-103. DOI:10.1055/a-2513-4313.

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