中枢神经淋巴系统解剖及其与神经系统疾病关系

doi:10.13418/j.issn.1001-165x.2025.2.07

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中国临床解剖学杂志 ›› 2025, Vol. 43 ›› Issue (2) : 151-156. DOI: 10.13418/j.issn.1001-165x.2025.2.07

淋巴外科创新技术

中枢神经淋巴系统解剖及其与神经系统疾病关系

范咏言，何培坤，李彦颐，王丽娟，聂坤*

作者信息 +

Recent advances in anatomy of central nervous lymphatic system and the relationship between it and nervous system diseases

Fan Yongyan, He Peikun, Li Yanyi, Wang Lijuan, Nie Kun*

Author information +

文章历史 +

摘要

近年来，中枢神经淋巴系统是神经科学研究的热点。中枢神经淋巴系统主要由星形胶质细胞足突围绕血管壁形成的胶质淋巴系统，以及脑膜静脉窦伴行的脑膜淋巴管组成，具有代谢废物清除、免疫功能、信号转导、物质运输和药物递送等功能，并受到水通道蛋白4、血流动力学、睡眠与昼夜节律等因素的调控。同时，该系统与神经退行性疾病、中枢神经系统脱髓鞘疾病、脑血管病等神经系统疾病的发生发展密切相关。本综述围绕中枢神经淋巴系统的解剖学结构、功能及其在神经系统疾病中的作用进行回顾，总结近年来的研究进展。

Abstract

Central nervous lymphatic system is an important breakthrough in neuroscience research in recent years. The anatomical structure of central nervous lymphatic system mainly includes glial lymphatic system formed around blood vessel wall of astrocyte foot process, and meningeal lymphatic vessels associated with meningeal venous sinus, which have metabolic waste clearance, immune function, signal transduction, material transport and drug delivery, and are regulated by AQP4, hemodynamics, sleep, and circadian rhythm and other factors. At the same time, the system is closely related to neurodegenerative diseases, central nervous system demyelinating diseases, cerebrovascular diseases, and other neurological diseases. This review focuses on anatomical structure, function, and role of nervous system diseases, and summarizes the research progress in recent years.

导出引用

范咏言, 何培坤, 李彦颐, 王丽娟, 聂坤. 中枢神经淋巴系统解剖及其与神经系统疾病关系[J]. 中国临床解剖学杂志. 2025, 43(2): 151-156 https://doi.org/10.13418/j.issn.1001-165x.2025.2.07

Fan Yongyan, He Peikun, Li Yanyi, Wang Lijuan, Nie Kun. Recent advances in anatomy of central nervous lymphatic system and the relationship between it and nervous system diseases[J]. Chinese Journal of Clinical Anatomy. 2025, 43(2): 151-156 https://doi.org/10.13418/j.issn.1001-165x.2025.2.07

中图分类号： R742.5

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