关键词: 骨性关节炎, 膝关节, 软骨, 磁共振成像, 3D-FS-SPGR序列

Abstract:

Objective　To detect cartilage thickness and pathological progress at various phases of osteoarthritis (OA) happened in articular genus using MR 3D-FS-SPGR sequence.　Methods　62 cases of OA were included in this study for detecting articular cartilage thickness by MR 3D-FS-SPGR sequence, followed by MRI scan. 20 young healthy volunteers were taken as controls and performed MRI detection.　Results　For gentle OA cases, there was no statistical difference of articular cartilage thickness with that in normal volunteers, however, articular cartilage in serious OA cases was significant different from that in the normal volunteers. In addition, multiple factors, such as sex, age, weight and BMI, might affect the thickness of knee articular cartilage.　Conclusions　By comparing of articular cartilage thickness between OA cases and healthy volunteers, the articular cartilage thickness in a bulk of cartilage weigh-loading surface attenuated gradually, following with the aggregated OA disease. Except for the degree of disease, it might be affected by multiple factors, such as weight, age, sex, and so on. 

Key words: Osteoarthritis (OA), Articular genu, Cartilage, Magnetic resonance imaging, 3D-FS-SPGR sequence