孕中晚期正常胎儿颈椎长度与胎龄关系的磁共振研究

doi:10.13418/j.issn.1001-165x.2016.02.009

中国临床解剖学杂志 ›› 2016, Vol. 34 ›› Issue (2): 160-164.doi: 10.13418/j.issn.1001-165x.2016.02.009

孕中晚期正常胎儿颈椎长度与胎龄关系的磁共振研究

赵慧¹，　林祥涛¹，　肖连祥¹，　吴勇¹，　董金叶¹，　张忠和²，　汤煜春²，　刘树伟²，　王光彬¹

1. 山东大学医学院山东省医学影像学研究所，济南 250012；　2.山东大学医学院断层影像解剖学研究中心，济南 250012

收稿日期:2014-08-16 出版日期:2016-03-25 发布日期:2016-04-14
通讯作者: 林祥涛，主任医师，博士生导师，E-mail: linxt@sdu.edu.cn
作者简介:赵慧(1988-)，女,山东临沂郯城县人，在读硕士，主要从事胎儿脊柱发育影像学研究，E-mail: zhaoiuh@126.com
基金资助:
国家自然科学基金（31371213）;山东省自然科学基金（ZR2013HM091）

MRI evaluation of fetal cervical spine length in normal second and third trimester of pregnancy

ZHAO Hui¹, LIN Xiang-tao¹, XIAO Lian-xiang¹, WU Yong¹， DONG Jin-ye¹， ZHANG Zhong-he²，TANG Yu-chun²，LIU Shu-wei²，WANG Guang-bing¹

1. Shandong Medical Imaging Research Institute,Jinan 250012, China; 2. Research Center for Sectional and Imaging Anatomy, School of Medicine of Shandong University, Jinan 250012, China

Received:2014-08-16 Online:2016-03-25 Published:2016-04-14

摘要/Abstract

摘要：

目的　研究正常胎儿标本颈椎长度与孕周变化的关系，绘制正常胎儿脊柱长度生长曲线。方法　本研究为前瞻性研究，利用3.0T MR扫描仪对65例16~42周自然流产及因母体或胎儿因素引产的胎儿标本行全脊柱3D-T2WI序列扫描，对所得图像进行三方位重建，在正中矢状位上测量颈椎长度及C4椎体的高度，建立相关线性回归方程。结果　胎儿颈椎长度及C4椎体高度与孕周的线性回归方程分别为：颈椎长度（cm）=0.193＋0.117孕周，R2 =0.94 ，P<0.05；C4椎体高度（cm）=0.025+0.013孕周，R2 =0.94，P<0.05。颈段脊柱发育有着时间的不平衡性，在生长发育过程中有两个发育高峰，分别为23~26孕周及31~34孕周；同样在这两个高峰，椎体高度增长速度较快。结论　孕中晚期，胎儿颈椎长度的增加与胎龄呈良好相关性，椎体的相关径线是评估胎儿脊椎发育的可靠指标。

关键词: , 胎儿标本, 颈椎长度, 生长发育, 磁共振成像

Abstract:

Objective 　Using the magnetic resonance imaging (MRI) to measure the normal fetal cervical spine length at different gestational ages，to investigate a more sensitive nomogram of fetal spine length and gestational ages. Methods　This research is a prospective study, Postmortem MR imaging was performed on 65 fetuses ranging from 16 to 42 gestational ages. 3D-T2WI of the whole spine was performed in sagittal plane and the images were reconstructed in the coronal , sagittal and axial planes to measure the length of the cervical spine segments and the 4th cervical vertebra in the midsagittal images. Liner regression equations were established. Results A statistically significant linear relationship was established between the lengths of cervical segments of the fetal spine and gestational ages, and the function were expressed by the regression as: Cervical length = 0.193＋0.117×gestational age，R2 =0.94；The C4 height=-0.586＋0.155×gestational age，R2 =0.94. At the same time, the development of the cervical segment and the 4th cervical vertebra is imbalanced. There were two peaks during growth stages,which were 23~26 gestational age and 31~34 weeks, respectively. Conclusions The fetal spine length appears as an easily acquired and valuable parameter， which strongly correlates with gestational age. Therefore it can be used to evaluate gestational age and to assess morphologic maturity of fetuses in the second and third trimester of pregnancy.

Key words: Fetal specimen, The length of the cervical spine, Growth and development, Magnetic resonance imaging

赵慧,林祥涛,肖连祥,吴勇,董金叶,张忠和,汤煜春,刘树伟,王光彬. 孕中晚期正常胎儿颈椎长度与胎龄关系的磁共振研究[J]. 中国临床解剖学杂志, 2016, 34(2): 160-164.

ZHAO Hui, LIN Xiang-tao, XIAO Lian-xiang, WU Yong, DONG Jin-ye,ZHANG Zhong-he,TANG Yu-chun，LIU Shu-wei，WANG Guang-bing. MRI evaluation of fetal cervical spine length in normal second and third trimester of pregnancy[J]. Chinese Journal Of Clinical Anatomy, 2016, 34(2): 160-164.

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孕中晚期正常胎儿颈椎长度与胎龄关系的磁共振研究

MRI evaluation of fetal cervical spine length in normal second and third trimester of pregnancy

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