中国临床解剖学杂志 ›› 2017, Vol. 35 ›› Issue (1): 57-61.doi: 10.13418/j.issn.1001-165x.2017.01.012

• 实验研究 • 上一篇    下一篇

慢性肌筋膜激痛点大鼠模型的剪切波弹性模量研究

吕恒勇1, 李真1, 王月香2, 李迎新1, 吴金鹏1   

  1. 1.中国医学科学院北京协和医学院生物医学工程研究所激光医学实验室,  天津   300192;
    2.解放军总医院超声科,  北京   100853
  • 收稿日期:2016-05-13 出版日期:2017-01-25 发布日期:2017-02-22
  • 通讯作者: 吴金鹏,助理研究员,Tel:13718609887, E-mail:microkn@126.com
  • 作者简介:吕恒勇(1980-),男,天津人,博士,主要从事弱激光医学、中医工程方面的研究,Tel:13821941736, E-mail:66507681@qq.com

Study of shear wave elastic modulus in a rat model of chronic myofascial trigger points

LV Heng-yong1, LI Zhen1, WANG Yue-xiang2, LI Ying-xin1, WU Jin-peng1   

  1. 1.Laser Medicine Laboratory, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China; 2.Department of Ultrasound, Chinese PLA General Hospital, Beijing100853, China
  • Received:2016-05-13 Online:2017-01-25 Published:2017-02-22
  • Contact: WU Jin-peng, E-mail:microkn@126.com

摘要:

目的 研究弹性超声在大鼠肌筋膜激痛点鉴定中的应用价值,为肌筋膜疼痛综合征等疾病的诊断研究提供依据。   方法 24只雄性SD大鼠(7周龄),随机分成对照组和模型组,模型组采取钝性打击结合离心运动的实验方法对其进行连续8周的干预,造模结束后,模型组与对照组均正常饲养4周,12周结束后通过电生理检测技术进行模型鉴定,并对激痛点行超声检查,检测激痛点的剪切波弹性模量,进一步分析比较组间差异。   结果 模型组大鼠股内侧肌肌电表现出异常自发电位,证明激痛点的存在;激痛点病灶区的剪切波弹性模量明显高于临近区(P <0.05),且模型组激痛点病灶区与临近区组织弹性模量均高于对照组。   结论 剪切波弹性模量测量方法可以量化激痛点的硬度特征,且提示激痛点病灶区硬度显著增大,可为临床触诊提供客观依据,实现对病灶区与临近区的有效鉴别,为鉴定激痛点动物模型提供了一种新方法,对于肌筋膜激痛点相关疾病的临床诊断与疗效评价具有重要的研究与应用价值。

关键词:  , 激痛点, 弹性模量, 超声弹性成像

Abstract:

Objective To detect the shear wave elastic modulus of the myofascial trigger points of chronic myofascial trigger points in a rat model, and study the application value of elastic ultrasound in the identification of the rat model and clinical diagnosis, and provide the basis for the diagnosis of the disease such as myofascial pain syndrome. Methods A total of 24 male SD rats (7 weeks old) were randomly divided into a control group (group A) and a model group (group B). A blunt striking injury and eccentric exercise were applied to the rats in the model group for 8 weeks, and then all rats were fed normally for 4 weeks. At the end of 12 weeks, EMG of rats was detected, and the elastic modulus of myofascial trigger point was measured by shear wave elastography and the difference between groups was compared. Results  Spontaneous electrical activity was detected in rats of group B, showing the existence of myofascial trigger points. The shear wave elastic modulus in focal region of the trigger point was significantly higher than that of the surrounding tissue (P<0.05), and the elastic modulus of the focal region and the surrounding tissue of the rats in the model group was higher than that of the control group. Conclusion Shear wave elasticity modulus measurement technique can quantify stiffness characteristics of myofascial trigger point, and prompt significant increase of the hardness of the trigger points, providing objective basis for clinical diagnosis. This technique can also be used to differentiate focal region and the surrounding tissue, providing a new way to identify the myofascial trigger point of the rat model. Therefore, this technique has an important study and application value for clinical diagnosis and treatment effect evaluation of myofascial pain syndrome.

Key words: Myofascial trigger point, Elastic modulus, Ultrasound elastrography