关键词: 动脉粥样硬化, 　流体力学, 　有限元, 　精确解剖, 　流固耦合

Abstract:

Objective　To investigate the hemodynamic characteristics of different degrees of stenosis in coronary artery under pulsating flow, which was performed with the help of accurate anatomical 3D models about coronary arteries having different degrees of stenosis, the models was established with CCTA data from living body. The contrast of hemodynamic parameters is obtained at different observation points; the contrast and changes of hemodynamic parameters and its influence on AS were also obtained.　Methods  Selecting cases from typical coronary stenosis ones, and then the CCTA data was obtained by  using the multiplies spiral CT. After that, FEM Models about coronary stenosis were estabilished with the software. At last the calculation and analysis were performed and the results were output in a variety of intuitive graphical forms.　Results　The flow velocity of the coronary artery stenosis accelerated, while it slowed down at the area behind the narrow and the eddy current was produced. This kind of change can have a great effect on plaques. Conclusion　The change of velocity played an important role in the development of AS, it can accurate the growth of atherosclerotic plaque and affect the stability.

Key words: Atherosclerosis；  , FEM；  , Precise anatomic；  , Fluid-structure interaction；　Hemodynamics