关键词: 机械性血管痉挛模型, 　显微重建外科, 　肌源性血管痉挛

Abstract: Objective　To establish a mechanical traction vasospasm model, for simulating vasospasm post-surgery. 　Methods　Forty-eight Sprague-Dawley rats were randomly divided into 6 groups: Group 1-5 was vascular traction groups (traction force was 5,10,15,20 and 25g, respectively); Group 6 was blunt vascular dissection group (control group). Laser Speckle contrast imaging was used to monitor the average blood flow perfusion, and to collect the duration of spasm and the time needed to achieve hyperperfusion as statistical parameters.　Results　Group 5 had hyperspasticity and was not included in the study. The duration and hyperperfusion time of vasospasm in group 1 and group 2 were relatively short, which was statistically significant compared with the control group (P<0.05). There was no significant difference between the third group and the control group (spasm duration P=0.801; hyperperfusion time P=0.629). Compared with the control group, the fourth group showed statistically significant difference in spasm duration (P=0.014), but no statistically significant difference in hyperperfusion duration (P=0.081). Conclusions　Vasospasm induced by bidirectional tension of 15g can well simulate clinical vascular dissection, and it is a reliable model with high success rate.

Key words: Mechanical vasospasm model, 　 Micro-reconstructive surgery, 　Myogenic vasospasm