弥散峰度成像对前交叉韧带早期退变性损伤的评估研究

doi:10.13418/j.issn.1001-165x.2023.5.05

中国临床解剖学杂志 ›› 2023, Vol. 41 ›› Issue (5): 527-530.doi: 10.13418/j.issn.1001-165x.2023.5.05

弥散峰度成像对前交叉韧带早期退变性损伤的评估研究

夏振元，蓝岚，莫欣鑫，杨成，余小平，李敏*

广西医科大学第二附属医院放射科，南宁 530007

收稿日期:2022-05-23 出版日期:2023-09-25 发布日期:2023-10-16
通讯作者: 李敏，副主任医师，硕士生导师，E-mail：hanbin2104 2332@126.com
作者简介:夏振元（1986-），男，广西南宁人，主治医师，研究方向：骨肌影像诊断，E-mail：2455096787@qq.com
基金资助:
广西壮族自治区临床重点专科建设项目（桂卫医发〔2020〕15号）

Assessment of anterior cruciate ligament degenerative injury by diffusion kurtosis imaging

Xia Zhenyuan, Lan Lan, Mo Xinxin, Yang Chen, Yu Xiaoping，Li Min*

Department of Radiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China

Received:2022-05-23 Online:2023-09-25 Published:2023-10-16

摘要/Abstract

摘要： 目的探讨弥散峰度成像（diffusion kurtosis imaging，DKI）评估前交叉韧带早期退变损伤的临床意义。方法收集2021年1月~2022年3月期间50例单膝关节DKI成像数据，据关节镜结果分为退变组（n=25）和正常组（n=25），对比两组患者前交叉韧带平均弥散峰度（mean kurtosis，MK）、轴向弥散峰度（axial kurtosis，AK）、径向弥散峰度（radial kurtosis，RK）、平均弥散系数（mean diffusivity，MD）及弥散各向异性分数（fractional anisotropy，FA）的差异性。结果退变组MK值、AK值、RK值以及FA值均低于正常组（t=8.132、5.313、6.885、9.035，均P<0.01），而MD值高于正常组（t=-5.145，P<0.01）。ROC曲线示DKI以上各参数对前交叉韧带早期退变性损伤均具有诊断意义，以MK值最高。当MK=0.884时，其诊断效能最大，敏感性92%，特异性96%，约登指数0.88，曲线下面积为0.979。结论弥散峰度成像可定量评估前交叉韧带早期退变损伤，为临床评估前交叉韧带生理退变提供参考。

关键词: 前交叉韧带, , , 损伤, , , 弥散峰度成像, , , 磁共振成像

Abstract: Objective To investigate the clinical value of diffusion kurtosis imaging (DKI) in assessing early degenerative injury of anterior cruciate ligament (ACL). Methods Fifty unilateral knees of patients underwent DKI scan were collected prospectively from January 2021 to March 2022. They were divided into a normal group (n=25) and a degeneration group (n=25) according to the results of arthroscopy examination. The differences of mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), mean diffusion (MD) and fractional anisotropy (FA) of ACL between two groups were compared. Results The MK value, AK value, RK value and FA value in the degeneration group were lower than those in the normal group significantly (t=8.132, 5.313, 6.885, 9.035, all P<0.01), while MD value were higher than that of the normal group (t=-5.145, P<0.01). The results of the ROC analysis revealed that the above DKI parameters had diagnostic value for ACL degenerative injury, and MK value had the highest diagnostic efficiency. When MK value was 0.884, its diagnostic efficiency was the highest. The sensitivity, specificity, Youden index and area under the ROC curve were 92%, 96%, 0.88 and 0.979, respectively. Conclusions Diffusion kurtosis imaging can quantitatively evaluate early degenerative injury of ACL, which providing reference for clinical evaluation of ACL physiological degeneration.

Key words: Anterior cruciate ligament, , , Injury, , , Diffusion kurtosis imaging, , , Magnetic resonance imaging

中图分类号:

R322.72

夏振元, 蓝岚, 莫欣鑫, 杨成, 余小平, 李敏. 弥散峰度成像对前交叉韧带早期退变性损伤的评估研究[J]. 中国临床解剖学杂志, 2023, 41(5): 527-530.

Xia Zhenyuan, Lan Lan, Mo Xinxin, Yang Chen, Yu Xiaoping, Li Min. Assessment of anterior cruciate ligament degenerative injury by diffusion kurtosis imaging [J]. Chinese Journal of Clinical Anatomy, 2023, 41(5): 527-530.

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弥散峰度成像对前交叉韧带早期退变性损伤的评估研究

Assessment of anterior cruciate ligament degenerative injury by diffusion kurtosis imaging

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