胎儿孤立性单侧侧脑室扩张对脑实质体积影响的MRI研究

doi:10.13418/j.issn.1001-165x.2023.1.03

中国临床解剖学杂志 ›› 2023, Vol. 41 ›› Issue (1): 15-19.doi: 10.13418/j.issn.1001-165x.2023.1.03

胎儿孤立性单侧侧脑室扩张对脑实质体积影响的MRI研究

孙珊珊¹，　田迷迷²，　赵鹏¹，　蔡硕¹，　杨涛²，　杨咏青²，　马文静¹，　林祥涛^1,2*

1.山东第一医科大学附属省立医院，山东济南 250021；2. 山东大学齐鲁医学院，山东济南 250021

收稿日期:2022-04-26 出版日期:2023-01-25 发布日期:2023-02-07
通讯作者: 林祥涛，教授，主任医师，E-mail：linxt@sdu.edu.cn
作者简介:孙珊珊（1994- ），女，山东菏泽人，硕士研究生，主要从事胎儿发育，E-mail：ssshan888@163.com
基金资助:
山东省自然科学基金（ZR2021MH216）；山东第一医科大学学术提升计划（2019QL023）

MRI study of the effect of isolated unilateral ventriculomegaly on the volume of brain parenchyma

Sun Shanshan¹, Tian Mimi², Zhao Peng¹,Cai Shuo¹, Yang Tao², Yang Yongqing², Ma Wenjing¹, Lin Xiangtao¹，²*

1. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250012, China; 2 Cheeloo College of Medicine, Shandong University, Jinan 250012, China

Received:2022-04-26 Online:2023-01-25 Published:2023-02-07

摘要/Abstract

摘要： 目的　研究不同程度单侧侧脑室扩张对脑实质体积的影响并探讨其对胎儿诊疗的临床价值。方法　收集经超声证实的孤立性单侧侧脑室扩张的胎儿，行胎儿颅脑1.5T MR扫描。测量扩张侧及正常侧的侧脑室宽度、相邻外侧脑实质厚度、侧脑室体积、大脑半球体积，并计算脑实质体积。每隔1月随访侧脑室宽度随孕周的变化情况。结果　最终纳入研究的23~31孕周的孤立性单侧侧脑室扩张胎儿共49例，按扩张程度分为3组：轻度扩张组12例、中度扩张组27例、重度扩张组10例。对比研究结果如下：① 3组病例的扩张侧与正常侧比较，扩张侧邻近脑实质厚度减小，脑实质体积未见明显差异；② 3组病例间的扩张侧侧脑室宽度、体积及大脑半球体积均存在差异（P<0.05），扩张侧脑实质厚度及体积未见明显差异；③ 随访发现轻中度扩张组侧脑室宽度逐渐减小者占76%，重度扩张组流产率达80%。结论　孤立性单侧侧脑室扩张对脑实质的体积没有影响，轻中度扩张胎儿预后好，这为侧脑室扩张胎儿的评估、预后和干预提供了重要影像学信息。

关键词: , 胎儿, , , 侧脑室, , , 孤立性侧脑室扩张, , , 脑实质, , , 磁共振成像

Abstract: Objective To investigate the effect of fetal isolated unilateral ventriculomegaly on the volume of brain parenchyma and its clinical value in fetal diagnosis and treatment. Methods Isolated unilateral ventriculomegaly confirmed by ultrasound underwent fetal brain examination at 1.5T MRI. The width of lateral ventricle, the thickness of adjacent lateral brain parenchyma, the volume of lateral ventricle and the volume of cerebral hemisphere were measured on the dilated side and the normal side, and the volume of brain parenchyma was calculated. The changes of the width of lateral ventricle with gestational age were followed up at an interval of 1 month. Results A total of 49 fetuses with isolated unilateral ventricular dilatation at 23-31 gestational weeks were finally included in the study. They were divided into three groups according to the degree of dilatation: 12 cases in the mild dilatation group, 27 cases in the moderate dilatation group and 10 cases in the severe dilatation group. The results of comparative study were as follows: ⑴ Compared with the normal side, the thickness of adjacent brain parenchyma on the dilated side decreased, and the volume of brain parenchyma was no significant difference; ⑵ There were differences in the width and volume of the dilated lateral ventricle and the volume of the cerebral hemisphere among the three groups (P<0.05), and there was no significant difference in the thickness and volume of the brain parenchyma on the dilated side. ⑶ The follow-up showed that the width of lateral ventricle gradually decreased in 76% in the mild and moderate dilation groups, and the abortion rate in the severe dilation group was 80%. Conclusions Isolated unilateral lateral ventricular dilatation has no effect on the volume of brain parenchyma, and the prognosis of fetuses with mild to moderate dilatation is good, which provides important imaging information for the evaluation, prognosis and intervention of fetuses with lateral ventricular dilatation.

Key words: Fetus , , , Ventricle, Isolated ventriculomegaly, , , Brain parenchyma, , , MRI

中图分类号:

R322
R445.2

孙珊珊, 田迷迷, 赵鹏, 蔡硕, 杨涛, 杨咏青, 马文静, 林祥涛. 胎儿孤立性单侧侧脑室扩张对脑实质体积影响的MRI研究[J]. 中国临床解剖学杂志, 2023, 41(1): 15-19.

Sun Shanshan, Tian Mimi, Zhao Peng, Cai Shuo, Yang Tao, Yang Yongqing, Ma Wenjing, Lin Xiangtao. MRI study of the effect of isolated unilateral ventriculomegaly on the volume of brain parenchyma[J]. Chinese Journal of Clinical Anatomy, 2023, 41(1): 15-19.

参考文献 15

[1]	李点杰, 潘石蕾, 卢丽玉, 等. 胎儿侧脑室增宽125例临床分析[J]. 现代妇产科进展, 2021,30(3):204-207. DOI: 10.13283/j.cnki.xdfckjz. 2021.03.011.
[2]	Pagani G, Thilaganathan B, Prefumo F. Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis[J]. Ultrasound Obstet Gynecol, 2014,44(3):254-260. DOI: 10.1002/uog.13364.
[3]	Ma HL, Zhao SX, Lv FR, et al. Volume growth trend and correlation of atrial diameter with lateral ventricular volume in normal fetus and fetus with ventriculomegaly: A STROBE compliant article[J]. Medicine (Baltimore), 2019,98(26):e16118. DOI: 10.1097/MD.00000000000 16118.
[4]	Kazan-Tannus JF, Dialani V, Kataoka ML, et al. MR volumetry of brain and CSF in fetuses referred for ventriculomegaly[J]. AJR Am J Roentgenol, 2007,189(1):145-151. DOI: 10.221 4/AJR.07.2073.
[5]	中华医学会放射学分会儿科学组, 中华医学会儿科学分会放射学组. 胎儿MRI中国专家共识[J]. 中华放射学杂志, 2020,54(12):1153-1161. DOI: 10.3760/cma.j.cn112149-202006 05-00779.
[6]	Mirsky DM, Stence NV, Powers AM, et al. Imaging of fetal ventriculomegaly[J]. Pediatr Radiol, 2020,50(13):1948-1958. DOI: 10.1007/s00247-020-04880-1.
[7]	Zhu R, Chen JY, Hou XL, et al. Asymmetric cortical development and prognosis in fetuses with isolated mild fetal ventriculomegaly: an observational prospective study[J]. BMC Pregnancy Childbirth, 2021,21(1):199. DOI: 10.1186/s12884-021-03692-x.
[8]	Ouahba J, Luton D, Vuillard E, et al. Prenatal isolated mild ventriculomegaly: outcome in 167 cases[J]. BJOG, 2006,113(9):1072-1079. DOI: 10.1111/j.1471-0528.2006.01050.x.
[9]	熊微, 李胜利, 林清秀, 等. 胎儿侧脑室扩张程度与妊娠结局[J]. 中华医学超声杂志(电子版), 2021,18(3):290-295. DOI: 10.3877/cma.j.issn.1672-6448.2021.03.009.
[10]	容蓉, 陈倩, 王霄英, 等. 胎儿侧脑室增宽的超声与MRI评估一致性分析[J]. 中国医学影像技术, 2016,32(12):1817-1821. DOI: 10.13929/j.1003-3289.2016.12.008.
[11]	付玏, 李克, 张军, 等. 孤立性侧脑室扩张胎儿脑的MRI弥散加权成像评估[J]. 中国医学计算机成像杂志, 2020,26(1):60-63. DOI: 10.19627/j.cnki.cn31-1700/th.2020.01.013.
[12]	Yaniv G, Katorza E, Bercovitz R, et al. Region-specific changes in brain diffusivity in fetal isolated mild ventriculomegaly[J]. Eur Radiol, 2016, 26(3):840-848. DOI: 10.1007/s00330-015-3893-y.
[13]	Scott JA, Habas PA, Rajagopalan V, et al. Volumetric and surface-based 3D MRI analyses of fetal isolated mild ventriculomegaly: brain morphometry in ventriculomegaly[J]. Brain Struct Funct, 2013,218(3):645-655. DOI: 10.1007/s00429-012-0418-1.
[14]	凌蕾, 王珏, 钱岚, 等. 基于MR图像的三维容积测量评价胎儿颅脑发育[J]. 中国优生与遗传杂志, 2020,28(8):986-991. DOI: 10.13404/j.cnki.cjbhh.2020.08.025.
[15]	Gilmore JH, Smith LC, Wolfe HM, et al. Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain[J]. Biol Psychiatry, 2008,64(12):1069-1076. DOI: 10.1016/j.biopsych. 2008.07.031.

胎儿孤立性单侧侧脑室扩张对脑实质体积影响的MRI研究

MRI study of the effect of isolated unilateral ventriculomegaly on the volume of brain parenchyma

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