SLA种植体表面喷涂钽形成纳米复合表面预防种植术后早期感染的动物体内实验研究

doi:10.13418/j.issn.1001-165x.2016.02.018

中国临床解剖学杂志 ›› 2016, Vol. 34 ›› Issue (2): 208-213.doi: 10.13418/j.issn.1001-165x.2016.02.018

SLA种植体表面喷涂钽形成纳米复合表面预防种植术后早期感染的动物体内实验研究

谢畅，　张宇，　张强

南方医科大学南方医院口腔种植科，南方医科大学口腔医学院, 广州 510515

收稿日期:2015-10-27 出版日期:2016-03-25 发布日期:2016-04-14
通讯作者: 张宇，博士，副主任医师，硕士研究生导师，E-mail: 70954954@qq.com
作者简介:谢畅（1990-），女，湖南湘潭人，医师，硕士，主要从事种植体表面处理的研究，Tel：（020）62787940，E-mail：xiechang 821111082@163.com
基金资助:
广东省科技计划项目（2013B010403012）

The influence of two different types of surface modification with implants in experimental peri-implantitis

XIE Chang, ZHANG Yu, ZHANG Qiang

Department of Oral Implantology, Nanfang Hospital, College of Stomatology, Southern Medical University, Guangzhou 510515, China

Received:2015-10-27 Online:2016-03-25 Published:2016-04-14

摘要/Abstract

摘要：

目的　探讨大颗粒酸蚀喷砂（Sandblasted/Large-grit/Acide -tched，SLA）表面处理的种植体与SLA表面喷涂钽（Ta）形成纳米复合表面的种植体对种植体周围炎发生发展的影响。方法　6只Beagle犬双侧前磨牙延期植入2种不同表面种植体。从左侧远中到右侧远中依次将植体记为1~6号，3、4号种植体设置非绑线的基线组，其余于基台颈部丝线结扎的方法建立犬种植体周围炎模型。分别在建模后四次对植体进行菌斑指数（plaque index, PI）、改良出血指数（modified Sulcus Bleeding Index, mSBI）、种植体周探诊深度（probing depth, PD）等临床指标测量，通过手术直观评价、显微CT扫描、组织学评价相结合观察种植体周骨缺损程度，对实验结果采用重复测量方差分析。结果　绑线的SLA组PI、mSBI、PD、垂直缺损与水平缺损深度等指标均显著高于绑线的SLA+Ta组（P<0.05）；显微CT扫描和组织学评价相结合观察可见绑线的SLA组较绑线的SLA+Ta组种植体周骨缺损明显。结论　SLA表面喷涂钽形成纳米复合表面的种植体较SLA表面处理的种植体延缓种植体周围炎的发生发展并减轻其症状。

关键词: 种植体, 表面处理, 种植体周围炎

Abstract:

Objective　To explore the influence of the occurance and development of experimental peri-implantitis between Sandblasted/Large-grit/Acide -tched (SLA) surface and nanoporous tantalum(Ta)-incorporated Sandblasted/Large-grit/Acide -tched (SLA) surface.　Methods　Two types of implants with different surface modification were implanted in the mandible of 6 Beagle dogs after the extraction of mandibular premolars. After prosthesis-abutment connection, suture line was twined to the neck of abutment in the experimental group, while there’s no suture in the control group. The implants were recorded sequentially from left to right of the distal as 1~6; 3、4 served as the control group while others served as the experimental group. Clinical indicators like plaque index, modified Sulcus Bleeding Index and probing depth were measured for 4 times. Micro-CT scan, surgical recording and pathological changes of peri-implant bone morphology were studied. MANOVA of repeated measuring was used.　Result　There were significant differences (P<0.05) for plaque index, modified Sulcus Bleeding Index and probing depth and surgical measurement between SLA+Ta twined with the suture group and SLA twined with the suture group, the degree of inflammation for SLA+Ta twined with the suture group were inferior to SLA twined with the suture group. Conclusion 　Implants with nanoporous tantalum(Ta)-incorporated Sandblasted/Large-grit/Acide -tched (SLA) surface shows postponed occurrence and development of peri-implantitis than Sandblasted/Large-grit/Acide -tched，(SLA) surface implants and can relieve the degree of inflammation.

Key words: Implant, Surface modification , Peri-implantitis

谢畅,张宇,张强. SLA种植体表面喷涂钽形成纳米复合表面预防种植术后早期感染的动物体内实验研究[J]. 中国临床解剖学杂志, 2016, 34(2): 208-213.

参考文献

[1] Klinger MM, Rahemtulla F, Prince CW, et al. Proteoglycans at the bone-implant interface [J]. Crit Rev Oral Biol Med, 1998, 9(4):449-463.
[2] 司家文,胡启凡,孙惠强.种植体表面抗菌涂层技术[J]. 口腔颌面修复学杂志, 2011, 12(2): 119-122.
[3] Sakka S, Baroudi K, Nassani MZ. Factors associated with early and late failure of dental implants [J]. J Investig Clin Dent, 2012, 3(4): 258-261.
[4] Schildhauer TA, Robie B, Muhr G, et al. Bacterial adherence to tatalum versus commonly used orthopedic metallic implant materials [J]. J Orthop Trauma, 2006, 20(7): 476-484.
[5] Vuong-Hung Pham, Tae-Sik Jang, Hyun-Do Jung. Creation of nanoporous tantalum(Ta)-incorporated titanium(Ti) surface onto Ti implants by sputtering of Ta in Ar under extremely high negative substrate biases[J]. Mater Chem, 2012, 22, 24798.
[6] Park SN, Son DH, Sung SJ. Effects of Ta addition through co-sputtering on the electrical characteristics of indium tin oxide thin film transitors[J]. J Nanosci Nanotechnol, 2015 15(1): 386-390.
[7] Shibli JA, Martins MC, Nociti Junior FH, et al. Treatment of ligature-induced peri-implantitis by lethal photosensitization and guided bone regeneration: a preliminary histologic study in dogs[J]. J Periodontol, 2003,74(3):338-345.
[8] Persson LG, Bergluudh T, Lindhe J, et al. Re-osseointegration after treatment peri-implantitis at different implant surfaces. An experimental study in the dogs.[J]. Clin Oral Implants Res, 2001,12(6):595-603.
[9] Machado MA, Stefani CM, Sallum EA, et al. Treatment of ligature-induced peri-implantitis defect by regenerative procedures: a clinical study in dogs[J]. J Oral Sci, 1999, 41(4):181-185
[10] 邹德荣, 朱红, 瞿晓辉. 种植体周围炎动物模型建立及意义[J]. 实用口腔医学杂志, 2005, 21(4): 463-466.
[11]Donley TG, Gillette WB. Titanium endosseous implant-soft tissue interface: a literature review [J]. J Periodontol, 1991, 62(2): 153-160.
[12]Pendegrass CJ, Goodship AE, Blunn GW. Development of a soft tissue seal around bone-anchored transcutaneous amputation prostheses [J]. Biomaterials, 2006, 27(23): 4183-4191.
[13]Mohandas G, Oskolkov N, McMahon MT. Porous tantalum and tantalum oxide nanoparticles for regenerative medicine [J]. Acta Neurobiol Exp, 2014, 74(2): 188-196.
[14]Reach JS Jr, Dickey ID, Zobitz MZ. Direct Tendon Attachment and Healing to Porous Tantalum: An Experimental Animal Study [J]. J Bone Joint Surg Am, 2007, 89(5): 1000-1009.
[15]Scarano A, Piattelli M, Caputi S, et al. Bacterial adhesion on commercially pure titanium and zirconium oxide disks: an in vivo human study [J]. J Periodontol, 2004, 75(2): 292-296.
[16]Zhu X, Chen J, Scheideler L, et al. Cellular reactions of osteoblasts to micron- and submicron-scale porous structures of titanium surfaces [J]. Cells Tissues Organs, 2004, 178(1): 13-22.
[17]Gristina AG, Naylor P, Myrvik Q. Infections from biomarerials and implants:a race for the surface [J]. Med Prog Technol, 1988, 14(3-4):205-224.
[18]Alberius P. Bone reactions to tantalum markers. A scanning electron microscopic study [J]. Acta Anat (Basel), 1983, 115(4): 310-318.

SLA种植体表面喷涂钽形成纳米复合表面预防种植术后早期感染的动物体内实验研究

The influence of two different types of surface modification with implants in experimental peri-implantitis

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