关键词: 大鼠, 动物模型, 脊柱融合, 骨移植

Abstract:

Objective　To compare the superiority and fusion rate of three different spinal fusion models in rats.　Methods　Sixty SD rats were randomized into three groups, A: underwent intervertebral fusions (with internal fixation); B: underwent posterolateral lumbar fusions (intertransverse); C: underwent intervertebral fusions (without internal fixation). For each group, palpation, X-ray, and histology were evaluated at 3 and 6 weeks after fusion.　Results　All groups did not show fusion 3 weeks after fusion. The fusion rate in A and B group were 40%. However, the fusion rate in C group was only 20% 6 weeks after fusion.　Conclusion　Intervertebral fusions and posterolateral lumbar fusions have good and enough bone graft bed, which are feasible and easy, therefore causing less postoperative complications. In conclusion, these operations are suitable for fusion model of rat which can enhance the rate of spinal fusion with bone substitute material. 

Key words:  Rats, Animal models, Spinal fusion, Bone transplantation