关键词: 颈动脉粥样硬化, 　颈部推拿, 　安全性, 　拉伸试验

Abstract:

Objective　To explore the effects of cervical manipulation on carotid artery atherosclerosis with severe stenosis in tensile mechanical properties.   Methods　45 healthy New Zealand white rabbits were divided into four groups randomly, including the Cervical Rotatory Manipulation(CRM) group (n=12), the manipulation of Pushing On Qiaogong (MPQ) group (n=12), the model control group (n=12) and the blank control group (n=9). In the CRM, the model control and the MPQ groups, rabbits models of carotid artery atherosclerosis were generated by carotid artery balloon injury combined with a high-fat diet. Then, manipulation of Pushing On Qiaogong or Cervical Rotatory Manipulation was applied on these rabbits in the MPQ group or CRM group separately for 3 weeks. Histological analysis and uniaxial failure test were performed in four groups in the end.    Results    (1) A total of 26 rabbits in the CRM, the model control and the MPQ groups had some typical atherosclerotic changes in carotid arteries as detected by color Doppler ultrasonography. (2) Compared to the blank control group, carotid arteries of other three groups had lower level of ultimate strain but higher level of ultimate load and elastic modulus. (3) Young's modulus increased more significantly in the CRM group than the model control group. Conclusion  The mechanical characteristics of the atherosclerotic rabbit artery decreased significantly than the normal artery. The cervical manipulation may decrease the tensile mechanical properties of the atherosclerotic rabbit carotid artery, which is valuable to explore the safety of cervical manipulation.

Key words:  , Carotid atherosclerosis, 　Cervical manipulation, 　Safety, 　Tensile test