人参皂苷Rbl对大鼠局灶性脑缺血白质重塑的影响

doi:10.13418/j.issn.1001-165x.2015.04.017

Chinese Journal Of Clinical Anatomy ›› 2015, Vol. 33 ›› Issue (4): 451-454.doi: 10.13418/j.issn.1001-165x.2015.04.017

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Effect of ginsenoside Rbl on white matter remodeling in rats with focal cerebral ischemia

HU Guang-qiang¹, ZHANG Hui³, XIAO Hong-wen¹, GAO Xiao-qing⁴, YANG Chao-xian⁴, YU Lu²

1.Department of Anatomy, Luzhou Medical College，Luzhou 646000，China；2. School of Basic Medical Sciences，Luzhou Medical College，Luzhou 646000，China；3. Department of Pharmacy, Leshan Fifth People's Hospital，Leshan 614900，China；4. Department of Neurobiology, Luzhou Medical College, Luzhou 646000, China

Received:2014-01-01 Online:2015-07-25 Published:2015-08-14

Abstract

Abstract:

Objective To investigate the effect of Ginsenoside Rbl (GSRb1) on white matter remodeling in rats with focal cerebral ischemia. Methods Rats were randomly divided into sham-operated group, vehicle-treated group and GSRb1-treated group, and MCAO/R (middle cerebral artery occlusion/reperfusion) model was induced by thread embolism; then pathological change of myelin sheath was observed by LFB staining in the cerebral corpus callosum and internal capsule, damage to astrocytes and axons was examined by GFAP and APP immunostaining. Results after 72 h following MCAO/R, obvious demyelination appeared in the corpus callosum and internal capsule and the expression of GFAP and APP was increased significantly in the corpus callosum. Compared with the vehicle-treated group, demyelination was significantly improved in GSRb1-treated group (P<0.01, P<0.05), and the expression GFAP and APP was greatly decreased in GSRb1-treated group (P<0.05). Conclusion Our findings suggest GSRb1 probably promote the white matter remodeling in rats with focal cerebral ischemia.

Key words: GSRbl, Focal cerebral ischemia, White matter remodeling

References

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Effect of ginsenoside Rbl on white matter remodeling in rats with focal cerebral ischemia

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