TAp73 和Beclin1在人骨肉瘤中表达及其临床意义

doi:10.13418/j.issn.1001-165x.2016.01.018

Abstract

Abstract:

Objective　To investigate the expression of TAp73 and Beclin1 in human osteosarcoma and their relationship.　Methods　The immunohistochemical SP method was used to detect the expressions of the TAp73 and Beclin1 proteins in 48 osteosarcoma patients’ tumor tissues, and the correlations of TAp73 and Beclin1 were analyzed with their clinical data.　Results　The positive rate of TAp73 was 54.17%, and the positive rate of Beclin1 was 60.42%. TAp73 positive expression, and the expression of Beclin1 were higher (Z=-2.146, P=0.032). The expression level of TAp73 was positively correlated with the expression of Beclin1 (P=0.001). The overall survival rate of patients with TAp73 and Beclin1 positive expression was better than that of negative expression (80.8% vs 50.0%, P=0.000, 80.0% vs 44.4%, P=0.001). The expression level of TAp73 and Beclin1 was positively correlated with the survival time of patients(r=0.696，P=0.00；r=0.372，P=0.009).　Conclusion　In human osteosarcoma, TAp73 may be related to the upregulation of Beclin1 dependent tumor autophagy activity. And to detect the expression of TAp73 and Beclin1 is helpful for the assessment of patients’ prognosis.

Key words: Osteosarcoma, Autophagy, TAp73, Beclin1, Prognosis

References

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Expression of TAp73 and Beclin1 in human osteosarcoma and their clinical significance

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