茶多酚对慢性酒精中毒肝损伤影响的实验研究

doi:10.13418/j.issn.1001-165x.2016.02.016

Abstract

Abstract:

Objective　To investigate the preventive effect of tea polyphenols from liver injury in chronic alcoholism, and explore its possible molecular mechanisms.　Methods　40 male kunming mice were divided into a control group, an alcohol group, a low dose group and a high dose group randomly. The mice model of alcoholic liver injury was duplicated by gavage and was given Alcohol and tea polyphenol respectively, using pure water as the control group. Then the mice′s AST, ALT, SOD, MDA, ROS, GSH-px,Bcl-2 and Bax of blood serum and liver tissue in each group weredetermined.　Result　The treatment medicine indicated that both the high or low doses of tea polyphenols could reduce the model of mice′s liver damage. Conclusion　The tea polyphenols could alleviate liver injury through inhibiting the preoxidation and eliminating free radicals.

Key words: Tea polyphenols, Alcohol poisoning, Liver, Bcl- 2, Bax

TANG Yin-juan，WANG Jian-jun,WANG Xiang-hai,PAN Meng-jie,CHEN Zhuo,XIAO Ling-long, LIU Jia-hua, CAI Wei-jun. The research of tea polyphenols for liver failure due to chronic alcoholic liver damage[J]. Chinese Journal Of Clinical Anatomy, 2016, 34(2): 198-201.

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The research of tea polyphenols for liver failure due to chronic alcoholic liver damage

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