Abstract:

Objective　To explore the expression and clinical significance of XK related, X-linked (XKRX) in colorectal cancer tissue.　Methods　The gene expression of XKRX and corresponding clinical data in colorectal cancer in TCGA public database were collected to make retrospective analysis and survival analysis. Quantitative real-time PCR and western blot were conducted to assess the expression of XKRX in 21 cases of colorectal cancer tissues.　Results　We found that the expression level of XKRX in colorectal cancer tissues was significantly higher than that of adjacent tissues (P<0.0001). The mRNA and protein expression level of XKRX in colorectal cancer tissues were significantly higher than that of the tissues adjacent to carcinoma. There was no significant difference between XKRX expression and gender (P= 0.9034), age (P=0.886), TMN stage (P=0.3979), lymph node metastasis (P=0.7995) and distant metastasis (P=0.6032). However, the survival time of the group with XKRX high expression was significantly lower than that of the group with low expression (P=0.0075).　Conclusion　Our data shows that XKRX is up-regulated in colorectal cancer tissues and may play a role in the proto-oncogene, which may affect the malignant progression of colorectal cancer and reduce the survival time of patients.

Key words: XKRX, 　XK related, X-linked, 　colorectal cancer, 　prognosis