槐耳颗粒联合术后辅助化疗对结直肠癌肝转移预后的影响

doi:10.13418/j.issn.1001-165x.2020.01.016

Abstract

Abstract: Objective　To investigate the clinical effects of Huaier granule combined with postoperative chemotherapy on recurrence and survival after curative resection of colorectal liver metastasis (CLM).　Methods　One hundred and twenty-eight patients with CLM who underwent curative resection at the sixth affiliated hospital, Sun Yat-sen University from January 2012 to December 2017 were followed up and analyzed retrospectively. Patients were divided into two groups according to the postoperative adjuvant therapy schedule. An experimental group: Huaier granule combined with chemotherapy (72 cases); a control group: only chemotherapy (56 cases). The following variables of two groups were analyzed: gender, age, carcinoembryonic antigen (CEA) lever, tumor depth, N stage, size of liver metastases, number of liver metastasis, chemotherapy before operation. The patients were followed up to November 2019. The followed up data were used to calculate the survival rate, and analyze the univariate factor and multivariate factor which affecting recurrence and long-term survival.　Results　The perioperative chemotherapy completion rate of the experimental group was higher than that of the control group. The 3-year and 5-year overall survival rates of the experimental group and the control group were 83.5%, 60.7% and 65.3%, 48.2%, respectively, with a significant difference (p=0.015).The recurrence free survival rates of the two groups were 77.8%, 53.5%, 59.7% and 35.7%, respectively, with a significant difference (p=0.003). Univariate and multivariate analysis showed that CEA level, lymph node metastasis, number of liver metastases and chemotherapy with perioperative completion affecting the postoperative recurrence of patients with CLM, primary tumors with lymph node metastasis, the number of liver metastases and Huaier Granule therapy affecting the overall survival.　Conclusions　The recurrence and overall survival of CLM after radical resection depend on the tumor burden and chemotherapy. The patients with single liver metastasis, no-lymph node metastasis and Huaier Granule combined with adjuvant chemotherapy, may have long-term survival.

Key words: Colorectal cancer; , , Liver metastasis; , , Huaier Granule

CLC Number:

R735.35

HUANG Liang, HU Huan-xin, LUO Shuang-ling, LIN Hong-cheng. Effect of Huaier granule combined with postoperative chemotherapy on recurrence and survival after curative resection of colorectal liver metastasis[J]. Chinese Journal of Clinical Anatomy, 2020, 38(1): 78-82.

References 16

[1]	Siegel RL, Miller KD, Jemal A.Cancer statistics 2017[J]. CA Cancer J Clin, 2017, 67(1):7-30.
[2]	Chen W, Zheng R, Baade PD，et al. Cancer statistics in China 2015[J].CA Cancer J Clin, 2016, 66(2):115-132.
[3]	Van Cutsem E, Nordlinger B, Cervantes A. Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment[J]. Ann Oncol, 2010, 21(Suppl 5):v93-97.
[4]	Van Cutsem E, Nordlinger B, Adam R, et al.Towards a pan-European consensus on the treatment of patients with colorectal liver metastases[J]. Eur J Cancer, 2006, 42(14):2212-2221.
[5]	沈永奇，黄军，陈超庭，等. 雷替曲塞联合奥沙利铂治疗中晚期原发性肝癌的临床研[J]. 川北医学院学报，2017，32( 1) : 57-59，63．
[6]	孙晓，徐恩松，邱春玉，等．微波消融术联合索拉非尼治疗原发性肝癌的效果观察[J]. 实用癌症杂志，2018, 33( 4) : 664-667．
[7]	Adam R, De Gramont A, Figueras J, et al. The oncosurgery approach to manag -ing liver metastases from colorectal cancer: a multidisciplinary international consensus[J]. Oncologist, 2012, 17(10): 1225-1239.
[8]	Dexiang Z, Li R, Ye W, et al. Outcome of patients with colorectal liver metastasis: analysis of 1,613 consecutive cases[J].Ann Surg Oncol, 2012,19(9):2860-2868.
[9]	Song X, Li Y, Zhang H, et al. The anticancer effect of Huaier (Review)[J]. Oncol Rep, 2015, 34(1):12-21.
[10]	Sun Y, Sun T, Wang F, et al. A polysaccharide from the fungi of Huaier exhibits antitumor potential and immunomodulatory effects[J]. Carbohydr Polym, 2013, 92(1):577-582.
[11]	Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides [J].Appl Microbiol Biotechnol 2002,60(3):258-274.
[12]	Schepetkin IA, Quinn MT. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential[J]. Int Immunopharmacol, 2006, 6(3):317-333.
[13]	Bao H, Liu P, Jiang K, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK[J]. Oncol Lett, 2016, 12(2):1058-1066.
[14]	Hu Z, Yang A, Su G, et al. Huaier restrains proliferative and invasive potential of human hepatoma SKHEP-1 cells partially through decreased Lamin B1 and elevated NOV[J]. Sci Rep, 2016, 6:31298.
[15]	Chen Q, Shu C, Laurence AD, et al. Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial[J]. Gut, 2018, 67(11):2006-2016.
[16]	崔佑刚, 孔祥余, 林峰, 等. 槐耳颗粒联合XELOX方案治疗Ⅳ期大肠癌的疗效研究[J]. 中国现代药物应用, 2016, 10(20):11-13.

Effect of Huaier granule combined with postoperative chemotherapy on recurrence and survival after curative resection of colorectal liver metastasis

Knowledge

Abstract

Cite this article

share this article

References 16

Related Articles 15

Metrics

Comments

Recommended 0

[1]	Jiang Jianhong, Duan Renpeng, Li Xiaofeng. Application of three-dimensional visualization technology in the anatomical variations of hilar bile ducts in Chinese population [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 1-4.
[2]	Guo Hongzhi, Wang Yu, Zhang Jiaqi, Liang Haibin, Ma Ziwei, Feng Wei, Wu You, Si Ziyi. Evaluation of placental vascular structure in preeclampsia by vascular casting combined with CT three-dimensional model [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 5-10.
[3]	Li Jiawei, Zhang Jing, Li Canran, Lan Wenjie, Ji Qingyu, Guo Zhiyong, Zhang Yunfeng, Liu Qi, Chen Qingwei, Li Xiaohe. X-ray measurement of proximal femur anatomical parameters in Mongolian population [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 11-16.
[4]	. Digital measurement and clinical significance of occipitocervical Angle and posterior occipitocervical Angle in children and adolescents [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 17-20.
[5]	Li Wen, Yang Siyi, Huang Lei, Qing Jiwen, Jiang Songtao, Zhang Lei. Morphological characteristics and clinical significance of Lisfranc ligament based on MRI [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 21-25.
[6]	Li Fanfan, Xu Yang, Wang Xiaoxu. Therapeutic effect of shikonin on the treatment of granuloma lobular mastitis in model rats by regulating Nrf2/HO-1 signaling pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 26-32.
[7]	Wang Xinghang, Ding Jiayuan, Li Fang, Bao Cuifen, Yan Lijing. Ginsenoside Rg1 reduces the inflammatory response of microglia after oxygen glucose deprivation/resupply by inhibiting the NLRP3 inflammasome pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 33-41.
[8]	Cheng Yingying, Wu Jianjun, Cai Haiyan , Jiao Xunwen, Ma Jiangbo, Ding Yinxiu. Activation and functional changes of astrocytes cultured in vitro under inflammatory stimulation [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 42-46.
[9]	Qi Zhi, Yang Li, Jia Qiuye, Chen Haolun, Duan Zhaoda, Wu Chunyun. Edaravone regulates Sirt3 expression in lipopolysaccharide-activated microglia via MAPKs signaling pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 47-53.
[10]	Zhang Jingjing, Wang Hongxin. Protective effect of Baicalin on rats with pulmonary hypertension through PDGF/P38 MAPK signaling pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 54-58.
[11]	Yue Qin, Chen Rongli, Xiong Jingxi, Wang Tingyi, Cai Zhiheng, Yi Qiushi, Zeng Xinyi. Effect of Bletilla striata polysaccharides on the choke-area of cross-boundary flap in rats [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 59-64.
[12]	Li Xiaoyu , Zhang Lei , Fu Lei , Li Dongbo , Wang Guoyou. Finite element study on the treatment of Sanders type II calcaneal fracture with three-step reduction method [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 65-70.
[13]	Wu Yanfei, Ma Jianxiong, Lu Bin, Wang Ying, Bai Haohao, Jin Hongzhen, Ma Xinlong. Study on the correlation between the reconstruction of grayscale values using CT post-processing technology and the compressive strength of the endplate [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 71-76.
[14]	Zhuang Wanqiang, Tang Yi, Luo Yonggang, Zhang Hui. An early and mid-term retrospective study of the effects of arthroscopy combined with high tibial osteotomy on patellar position and patellofemoral joint function [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 77-82.
[15]	Luo Ying, Dou Weiyu, Wu Xiaohang, Chen Jingkun, Peng Changgui, Pan Jianying . Risk factors of postoperative complications of calcaneal fractures treated with hippocampal plate internal fixation through minimally invasive method [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 83-88.