缺血性卒中患者脑运动区域协调性功能影像学研究

doi:10.13418/j.issn.1001-165x.2020.04.006

Abstract

Abstract: Objective　To evaluate the correlation between craniocerebral neuroanatomy and regional brain function in patients with ischemic stroke, and to further explore the neural mechanism of ischemic stroke.　Methods　15 healthy patients in a control group and 19 patients with upper limb hemiplegia in subacute ischemic stroke were collected. The functional connection index of the internal craniocerebral hemisphere was calculated by using computational neuroimaging, and the clinical rehabilitation score before and after treatment was collected for statistical correlation analysis.　Results　(1) Compared with the control group, cerebral hemispheric functional connectivity significantly reduced in stroke patients, with statistically significant differences (T=-10.077, P<0.001). (2) The abnormal focus of lesions was in the supplementary motor area (P=0.02) and the anterior central gyrus (P=0.03), and the difference was statistically significant. (3) The functional connection value in the anterior central gyrus of the patient group before and after drug treatment was positively correlated with the rehabilitation scoring scale, and the difference was statistically significant (r=0.29, P=0.03).　Conclusions　The decrease of functional connections of hemispheres in cerebral motor areas in patients with subcortical ischemic stroke may provide a new approach for clinical diagnosis and rehabilitation evaluation.

Key words: Ischemic stroke, 　Tomography, 　Functional connectivity, 　Cortical motor area, Rehabilitation score

CLC Number:

R743.3

LI Ding, WANG Ya, WANG Yan-fang, CHEN Yan-jun, LI Jing-ming, HUANG Wen-hua. Imaging study of regional coordination function of cerebral motor in patients with ischemic stroke[J]. Chinese Journal of Clinical Anatomy, 2020, 38(4): 391-395.

References 17

[1]	Freedman B, Potpara TS, Lip GY. Stroke prevention in atrial fibrillation[J]. The Lancet, 2016, 388(10046): 806-817.
[2]	Goyal M, Demchuk AM, Menon BK. Randomized assessment of rapid endovascular treatment of ischemic stroke[J]. N Engl J Med, 2015, 372(11):1019-1930.
[3]	Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association[J]. stroke, 2011, 42(9): 2672-2713.
[4]	Román GC, Erkinjuntti T, Wallin A, et al. Subcortical ischaemic vascular dementia[J]. Lancet Neurol, 2002, 1(7): 426-436.
[5]	Zhang Y, Liu H, Wang L, et al. Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study[J]. Neuroradiology, 2016, 58(5): 503-511.
[6]	Zheng XH, Sun LM, Yin DZ,et al. The plasticity of intrinsic functional connectivity patterns associated with rehabilitation intervention in chronic stroke patients[J]. Neuroradiology, 2016, 58(4): 417-427.
[7]	Page SJ, Fulk GD, Boyne P. Clinically important differences for the upper-extremity Fugl-Meyer Scale in people with minimal to moderate impairment due to chronic stroke[J]. Phys Ther, 2012, 92(6): 791-798.
[8]	Winters C, van Wegen EE, Daffertshofer A, et al. Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke[J]. Neurorehabil Neural Repair, 2015, 29(7): 614-622.
[9]	Lam TK, Dawson DR, Honjo K, et al. Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke[J]. J Neurol Sci, 2018, 384:21-29.
[10]	Chao-Gan Y, Yu-Feng Z. DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI[J]. Front Syst Neurosci, 2010, 4: 13.
[11]	Li Y, Wang D, Zhang H, et al. Changes of brain connectivity in the primary motor cortex after subcortical stroke: a multimodal magnetic resonance imaging study[J]. Medicine (Baltimore), 2016. 95(6): e2579.
[12]	Klingbeil J, Wawrzyniak M, Stockert A, et al. Resting-state functional connectivity: An emerging method for the study of language networks in post-stroke aphasia[J]. Brain Cogn, 2019, 131: 22-33
[13]	Kelly C, Zuo XN, Gotimer K, et al. Reduced interhemispheric resting state functional connectivity in cocaine addiction[J]. Biol Psychiatry, 2011, 69(7): 684-692.
[14]	Kalinosky BT, Barillas RB, Schmit BD. Structurofunctional resting-state networks correlate with motor function in chronic stroke[J]. Neuroimage Clin, 2017, 16: 610-623.
[15]	Li S. Spasticity, motor recovery, and neural plasticity after stroke[J]. Front Neurol, 2017, 8: 120.
[16]	Zuo XN, Kelly C, Martino AD, et al. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy[J]. J Neurosci, 2010, 30(45): 15034-15043.
[17]	Itabashi R, Nishio Y, Kataoka Y, et al. Damage to the left precentral gyrus is associated with apraxia of speech in acute stroke[J]. Stroke, 2016, 47(1): 31-36.

Imaging study of regional coordination function of cerebral motor in patients with ischemic stroke

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