润燥止痒胶囊对银屑病样皮损大鼠肠道菌群和炎症反应的影响

doi:10.13418/j.issn.1001-165x.2020.05.016

Abstract

Abstract: Objective　To explore the effects of Runzao Zhiyang capsule (RZC) on psoriatic lesions from the perspective of regulation on gut microbiota and immune inflammation.　Methods　Effect of RZC on rat model with psoriatic lesions was studied. Levels of inflammatory cytokines (IL-6、TNF-α、IL-17 and IL-10) in the plasma were detected. The number of major bacterial colonies in feces was analyzed.　Results　After treatment with RZC for two weeks, symptoms of psoriatic lesions in rats were significantly improved. The levels of IL-17, IL-6, and TNF-α in the plasma were down-regulated by RZC, but the IL-10 level was up-regulated by RZC, respectively, which indicating the amelioration of inflammatory response. RZC also reduced the amounts of escherichia and enterococcus, and increased the number of lactobacillus and bifidobacteria in the gut.　Conclusions　RZC treats psoriatic lesions, which maybe related to modulating gut microbial structure, and ameliorating immune inflammatory response of the host.

Key words: Runzao Zhiyang capsule; , , Psoriatic lesion; , , Gut microbiota; , , Inflammatory response

CLC Number:

R758.63

HU Hui-ying, HU Yin-xia, LIU Chang-shun, SU Xiao-ting, DAI Hui. Effects of Runzao Zhiyang capsule on gut microbiota and inflammatory response in rats with psoriatic lesions[J]. Chinese Journal of Clinical Anatomy, 2020, 38(5): 574-577.

References 12

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Effects of Runzao Zhiyang capsule on gut microbiota and inflammatory response in rats with psoriatic lesions

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