小剂量超短波对脊髓损伤功能恢复及对血清iNOS、TNF-α、VEGF、BDNF表达的影响

doi:10.13418/j.issn.1001-165x.2020.05.019

Abstract

Abstract: Objective　To investigate the effect of low-dose ultrashort wave on functional recovery and serum inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) expression.　Methods　Sixty patients with spinal cord injury were enrolled and randomly divided into a treatment group and a control group, with 30 cases in each group. The control group was given basic rehabilitation treatment, and the treatment group was treated with small dose ultrashort wave therapy for a total of 3 courses of treatment. Efficacy was assessed and factors affecting spinal function recovery were analyzed.　Results　The total effective rate of the treatment group was higher than that of the control group (P<0.05). After rehabilitation treatment, the motor function and sensory function scores of the ASIA scale in the treatment group were higher than those in the control group (P<0.05). The levels of serum VEGF and BDNF in the treatment group were higher than those in the control group (P<0.05). The expression levels of iNOS and TNF-α in the treatment group were lower than those in the control group (P<0.05). Low dose ultrashort wave therapy was a protective factor for prognosis of patients with spinal cord injury (P<0.05).　Conclusions　Low-dose ultrashort wave adjuvant therapy can significantly promote the recovery of spinal cord function in patients, which may be related to down-regulation of serum iNOS, TNF-α expression and up-regulation of VEGF and BDNF expression.

Key words: , Ultrashort wave；　Spinal cord injury；　Spinal cord function；　iNOS；　TNF-α

CLC Number:

R493

LIANG Ai-ping, LI Wen-hui . Effect of low-dose ultrashort wave on functional recovery and expression of serum iNOS, TNF-α, VEGF, and BDNF in patients with spinal cord injury[J]. Chinese Journal of Clinical Anatomy, 2020, 38(5): 588-592.

References 15

[1]	Spinal cord injury (SCI) 2016 facts and figures at a glance[J]. J Spinal Cord Med, 2016, 39(4): 493-494.
[2]	吴猛, 李雄锋, 吴玮, 等. 神经节苷脂联合康复训练对脊髓损伤患者炎性因子及神经功能恢复的影响[J]. 中国临床药理学杂志, 2016, 32(12):1081-1084.
[3]	李敏, 杨孝, 孙年怡, 等. 脊髓损伤中TNF-α诱导细胞凋亡和坏死性凋亡的研究进展[J]. 广东医学, 2018, 39(18):2841-2844.
[4]	孙师, 万峪岑, 赵利娜, 等. 骨髓间充质干细胞联合超短波对大鼠脊髓损伤后早期AQP-4和GAP-43的影响[J]. 中国康复医学杂志, 2016,31(6): 625-631.
[5]	敖强, 吕德成, 姜长明, 等. 脊髓损伤后细胞凋亡及iNOS的表达[J]. 中国康复理论与实践, 2003, 9(1):38-41.
[6]	美国脊髓损伤协会, 国际脊髓损伤学会, 李建军, 等. 脊髓损伤神经学分类国际标准(2011年修订)[J]. 中国康复理论与实践, 2011, 17(10):963-971.
[7]	Lammertse D, Tuszynski MH, Steeves JD, et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. [J]. Spinal Cord, 2007, 45(3):232-242.
[8]	张士杰. 临床脊柱外科学[M]. 北京: 科学技术文献出版社, 2008:39-42.
[9]	Nam KY, Kim HJ, Kwon BS, et al. Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: a systematic review.[J]. J Neuroeng Rehabil, 2017, 14(1):24.
[10]	万峪岑, 孙师, 赵利娜, 等. 小剂量超短波治疗对大鼠脊髓损伤后炎症反应及水肿的影响[J]. 中国康复理论与实践, 2016, 22(2):150-155.
[11]	周刚, 王佳君. 高频电疗对急性脊髓损伤大鼠神经功能恢复和BDNF-TrkB表达的影响[J]. 颈腰痛杂志, 2018, 39(6): 694-697.
[12]	万峪岑, 孙师, 冯智萍, 等. 小剂量超短波治疗对大鼠脊髓损伤后VEGF和BDNF的影响[J]. 中国康复医学杂志, 2018, 33(8): 891-895.
[13]	尹振春, 董英海, 朱菁, 等. He-Ne激光对急性脊髓损伤总NOS、iNOS和ET-1的影响[J]. 应用激光, 2005, 25(3):214-216.
[14]	祝志强, 李佳, 孙晴, 等. 虎杖苷对急性脊髓损伤大鼠氧化应激反应和炎症反应影响[J]. 临床军医杂志, 2018, 46(4):435-438.
[15]	张军卫, 唐和虎, 李想, 等. Denis,Magerl和AO2013三种胸腰椎损伤分类方法的对比分析[J]. 中华骨与关节外科杂志, 2017, 10(4):312-316.

Effect of low-dose ultrashort wave on functional recovery and expression of serum iNOS, TNF-α, VEGF, and BDNF in patients with spinal cord injury

Knowledge

Abstract

Cite this article

share this article

References 15

Related Articles 15

Metrics

Comments

Recommended 0

[1]	Jiang Jianhong, Duan Renpeng, Li Xiaofeng. Application of three-dimensional visualization technology in the anatomical variations of hilar bile ducts in Chinese population [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 1-4.
[2]	Guo Hongzhi, Wang Yu, Zhang Jiaqi, Liang Haibin, Ma Ziwei, Feng Wei, Wu You, Si Ziyi. Evaluation of placental vascular structure in preeclampsia by vascular casting combined with CT three-dimensional model [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 5-10.
[3]	Li Jiawei, Zhang Jing, Li Canran, Lan Wenjie, Ji Qingyu, Guo Zhiyong, Zhang Yunfeng, Liu Qi, Chen Qingwei, Li Xiaohe. X-ray measurement of proximal femur anatomical parameters in Mongolian population [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 11-16.
[4]	. Digital measurement and clinical significance of occipitocervical Angle and posterior occipitocervical Angle in children and adolescents [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 17-20.
[5]	Li Wen, Yang Siyi, Huang Lei, Qing Jiwen, Jiang Songtao, Zhang Lei. Morphological characteristics and clinical significance of Lisfranc ligament based on MRI [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 21-25.
[6]	Li Fanfan, Xu Yang, Wang Xiaoxu. Therapeutic effect of shikonin on the treatment of granuloma lobular mastitis in model rats by regulating Nrf2/HO-1 signaling pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 26-32.
[7]	Wang Xinghang, Ding Jiayuan, Li Fang, Bao Cuifen, Yan Lijing. Ginsenoside Rg1 reduces the inflammatory response of microglia after oxygen glucose deprivation/resupply by inhibiting the NLRP3 inflammasome pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 33-41.
[8]	Cheng Yingying, Wu Jianjun, Cai Haiyan , Jiao Xunwen, Ma Jiangbo, Ding Yinxiu. Activation and functional changes of astrocytes cultured in vitro under inflammatory stimulation [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 42-46.
[9]	Qi Zhi, Yang Li, Jia Qiuye, Chen Haolun, Duan Zhaoda, Wu Chunyun. Edaravone regulates Sirt3 expression in lipopolysaccharide-activated microglia via MAPKs signaling pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 47-53.
[10]	Zhang Jingjing, Wang Hongxin. Protective effect of Baicalin on rats with pulmonary hypertension through PDGF/P38 MAPK signaling pathway [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 54-58.
[11]	Yue Qin, Chen Rongli, Xiong Jingxi, Wang Tingyi, Cai Zhiheng, Yi Qiushi, Zeng Xinyi. Effect of Bletilla striata polysaccharides on the choke-area of cross-boundary flap in rats [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 59-64.
[12]	Li Xiaoyu , Zhang Lei , Fu Lei , Li Dongbo , Wang Guoyou. Finite element study on the treatment of Sanders type II calcaneal fracture with three-step reduction method [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 65-70.
[13]	Wu Yanfei, Ma Jianxiong, Lu Bin, Wang Ying, Bai Haohao, Jin Hongzhen, Ma Xinlong. Study on the correlation between the reconstruction of grayscale values using CT post-processing technology and the compressive strength of the endplate [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 71-76.
[14]	Zhuang Wanqiang, Tang Yi, Luo Yonggang, Zhang Hui. An early and mid-term retrospective study of the effects of arthroscopy combined with high tibial osteotomy on patellar position and patellofemoral joint function [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 77-82.
[15]	Luo Ying, Dou Weiyu, Wu Xiaohang, Chen Jingkun, Peng Changgui, Pan Jianying . Risk factors of postoperative complications of calcaneal fractures treated with hippocampal plate internal fixation through minimally invasive method [J]. Chinese Journal of Clinical Anatomy, 2024, 42(1): 83-88.