Chinese Journal of Clinical Anatomy ›› 2022, Vol. 40 ›› Issue (1): 67-71.doi: 10.13418/j.issn.1001-165x.2022.1.13

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Establishment of a new mechanical traction vasospasm model

Ma Qiming1, Cao Chenxin1, Chen Shaofeng1, Xie Yun2*   

  1. 1. Department of Human Anatomy, Histology and Embryology, Fujian Medical University, Fuzhou 350108, China; 2. Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
  • Received:2020-08-04 Online:2022-01-25 Published:2022-01-19

Abstract: Objective To establish a mechanical traction vasospasm model, for simulating vasospasm post-surgery.  Methods Forty-eight Sprague-Dawley rats were randomly divided into 6 groups: Group 1-5 was vascular traction groups (traction force was 5,10,15,20 and 25g, respectively); Group 6 was blunt vascular dissection group (control group). Laser Speckle contrast imaging was used to monitor the average blood flow perfusion, and to collect the duration of spasm and the time needed to achieve hyperperfusion as statistical parameters. Results Group 5 had hyperspasticity and was not included in the study. The duration and hyperperfusion time of vasospasm in group 1 and group 2 were relatively short, which was statistically significant compared with the control group (P<0.05). There was no significant difference between the third group and the control group (spasm duration P=0.801; hyperperfusion time P=0.629). Compared with the control group, the fourth group showed statistically significant difference in spasm duration (P=0.014), but no statistically significant difference in hyperperfusion duration (P=0.081). Conclusions Vasospasm induced by bidirectional tension of 15g can well simulate clinical vascular dissection, and it is a reliable model with high success rate.

Key words: Mechanical vasospasm model,   Micro-reconstructive surgery,  Myogenic vasospasm

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