Abstract: Objective    To investigate the application value of CT perfusion imaging in liver cirrhosis patients with portal hypertension (PHT) before and after transjugular intrahepatic portosystemic shunt.  Methods    A retrospective analysis of 62 patients with PHT of liver cirrhosis who underwent transjugular intrahepatic portosystemic shunt in our hospital from January 2018 to January 2020 was performed. The CT images before and after transjugular intrahepatic portosystemic shunt was collected.  The perfusion of hepatic artery and portal vein before and after the intrahepatic portal shunt of internal jugular vein were calculated to analyze the differences of CT perfusion parameters . Then, according to the treatment effect, the AEF values of each group were calculated. The serum examination results before and after operation were collected, and the MELD score of patients was calculated.    Results   The HAP and HPI of patients after operation were significantly improved compared with those before operation. There was no significant difference in hepatic portal vein before and after operation. There were statistically significant differences in several perfusion parameters before and after operation (P<0.05). AEF increased after operation, and the difference was statistically significant (P<0.05).The MELD value of PHT patients with liver cirrhosis increased after operation, and the difference was statistically significant compared with that before operation (P<0.05).     Conclusions    Hepatic CT perfusion imaging can reflect the changes of hepatic microcirculation before and after transjugular intrahepatic portosystemic shunt in PHT patients with liver cirrhosis, and transjugular intrahepatic portosystemic shunt does not worsen the liver function.

Key words: Liver cirrhosis; ,  PHT; ,  Transjugular intrahepatic portosystemic shunt; ,  Perfusion imaging