Abstract: Objective    To analyze the effect of paternal age on pregnancy outcome.    Methods    A total of 185,104 women who delivered in Nanshan District between January 2011 and December 2020. The paternal age were recorded. Logistic regression analysis and generalized linear regression model was used to analyze the association between paternal advanced age and adverse pregnancy outcomes after adjustment for maternal age, ethnicity, and education.    Results    (1) Paternal age ranged from 15 to 85 years with a median of 31 years (interquartile difference, 27 to 34 years) and maternal age ranged from 14 to 51 years with a median of 29 years (interquartile difference, 26 to 32 years) . (2) In unadjusted analyses, the higher rates of pregnancy complications occurred in the paternal age group of 40~49 years and ≥50 years, and the lower rates of unadjusted pregnancy complications occurred in the paternal age group of <40 years. (3) After adjusted maternal age and other risk factors, increasing paternal age did not appear to be associated with increased incidence of structural abnormalities, preeclampsia, eclampsia, gestational diabetes, placental abruption, postpartum hemorrhage (≥500 ml) , preterm birth, premature rupture of membranes and stillbirth. Conclusions     Results adjusted for maternal age indicated that paternal age had no significant effect on adverse pregnancy outcomes. The maternal age mainly contributed to the observed effect of paternal age.

Key words: Paternal age,  ,  ,  , Pregnancy outcome,  ,  ,  , Structural malformation