Abstract: Objective    To study the vascular casting and CT digital three-dimensional structure model of placental vessels in preeclampsia, and statistically analyze the anatomical characteristics of placental vessels in preeclampsia, so as to provide technical data for clinical prediction of preeclampsia.  Methods  Totally 134 cases of placentas with gestational weeks ≥ 34 weeks (68 normal placenta, among 66 preeclampsia, 36 were mild and 30 were severe ) were randomly collected from November 2018 to June 2020. The placental vascular cast models were constructed by adding barium sulfate as a contrast agent to the self-coagulating denture powder. Then, the placental vascular cast models were scanned by CT and digital three-dimensional structure models were obtained. The number of placental arteriovenous grades, the diameters of various branches and the volume of placental arteriovenous vessels in the cast models were measured and compared.   Results   The placental vascular volume and placental vein volume of late-onset severe preeclampsia were smaller than those of normal group and mild preeclampsia group (P<0.05). Compared with the placentas of normal group and mild preeclampsia in the same period, the placentas of late-onset severe preeclampsia had fewer grades of placental veins and narrower branches (P<0.05),  the number of placental artery grades in late-onset severe preeclampsia group decreased and the diameter of the third and fourth branches of the artery became smaller (P<0.05).    Conclusions   Vascular casting combined with CT 3D model is helpful to understand the vascular structure of placenta in preeclampsia intuitively and comprehensively.

Key words: Vascular casting,  ,  , CT three-dimensional model,  ,  , Placenta,  ,  , Preeclampsia