Expert consensus on lymphatic surgical treatment for Alzheimer's disease（2025 edition）

doi:10.13418/j.issn.1001-165x.2025.2.01

PDF(716 KB)

Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (2) : 121-127. DOI: 10.13418/j.issn.1001-165x.2025.2.01

Expert consensus on lymphatic surgical treatment for Alzheimer's disease（2025 edition）

Xie Qingping^1,17, Wang Yilong², Pan Weiren³, Yang Xiaodong⁴, Guo Hui⁵, Xiao Ming⁶, Wang Haiwen⁷, Mao Zhiqi⁸, Zheng Xiaoju⁹, Fu Xiaohong¹⁰, Liu Jun¹¹, Xiong Lingyun¹², Xu Zhipeng¹³, Lu Yun¹⁴, Yuan Xueqian¹⁵, Hou Jianxi¹⁶, Pan Yuesong²

Author information +

1. Department of Plastic Surgery, Hangzhou Qiushi Hospital, Hangzhou 310022, Zhejiang Province, China; 2. Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; 3. Department of Anatomy, School of Basic Medicine, Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China; 4. Department of Hand Surgery and Reconstructive Surgery, Zhejiang Provincial People's Hospital (People's Hospital Affiliated to Hangzhou Medical College), Hangzhou 310014, Zhejiang Province, China; 5. Shanghai Deji Hospital, Shanghai Brain Center of Qingdao University, Shanghai 200333, China; 6. Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China; 7. Chashan Hospital, Dongguan 523000, Guangdong Province, China; 8. Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; 9. Department of Microsurgery, Fengcheng Hospital, Xi'an Medical University, Xi'an 710016, Shaanxi Province, China; 10. Department of Neurosurgery, Zunyi First People's Hospital (The Third Affiliated Hospital of Zunyi Medical University), Zunyi 563000, Guizhou Province, China; 11. Department of Hand Surgery, The Second Hospital of Jilin University, Changchun 130022, Jilin Province, China; 12. Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China; 13. Department of Anesthesiology, Shanghai Pudong Hospital, Shanghai 200137, China; 14. Department of Hand, Foot, and Reconstructive Surgery, the First Affiliated Hospital of Nankai University, Tianjin 300222, China; 15. Department of Neurology, Zhengzhou Second People's Hospital, Zhengzhou 450052, Henan Province, China; 16. Department of Microsurgery, Zhengzhou Renji Hospital, Zhengzhou 450047, Henan Province, China; 17. Department of Microsurgery, Hangzhou Huagong Hospital, Hangzhou 310024, Zhejiang Province, China

Show less

History +

Key words

Lymphatic surgery / / / Alzheimer's disease / / / Expert consensus

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Xie Qingping, Wang Yilong, Pan Weiren, Yang Xiaodong, Guo Hui, Xiao Ming, Wang Haiwen, Mao Zhiqi, Zheng Xiaoju, Fu Xiaohong, Liu Jun, Xiong Lingyun, Xu Zhipeng, Lu Yun, Yuan Xueqian, Hou Jianxi, Pan Yuesong. Expert consensus on lymphatic surgical treatment for Alzheimer's disease（2025 edition）[J]. Chinese Journal of Clinical Anatomy. 2025, 43(2): 121-127 https://doi.org/10.13418/j.issn.1001-165x.2025.2.01

References

[1] 卢鸿瑞, 谭云飞, 谢庆平. 3D脱目镜下行颈深淋巴管-静脉引流术治疗老年认知障碍患者一例疗效初步观察[J]. 中华显微外科杂志, 2022, 45(5): 570-574. DOI：10.3760/cma.j.cn441206-20210809-00194.
[2] Xie Q, Louveau A, Pandey S, et al. Rewiring the brain: the next frontier in supermicrosurgery[J]. Plast Reconstr Surg, 2024, 153(2):494e-495e. DOI: 10.1097/PRS.0000000000010933.
[3] Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels[J]. Nature, 2015, 523(7560):337-341. DOI: 10.1038/nature14432.
[4] Wang L, Zhang Y, Zhao Y, et al. Deep cervical lymph nodeligation aggravates AD-like pathology of APP/PS1 mice[J]. Brain Pathol, 2019, 29(2):176-192. DOI: 10.1111/bpa.12656.
[5] Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders[J]. Lancet Neurol, 2018, 17(11):1016-1024. DOI: 10.1016/S1474-4422(18)30318-1.
[6] Feng W, Zhang Y, Wang Z, et al. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance[J]. Alzheimers Res Ther, 2020,12(1):125. DOI: 10.1186/s13195-020-00688-1.
[7] Da Mesquita S, Fu Z, Kipnis J. The meningeal lymphatic system: a new player in neurophysiology[J]. Neuron, 2018, 100(2):375-388. DOI: 10.1016/j.neuron.2018.09.022.
[8] Hu X, Deng Q, Ma L, et al. Meningeal lymphatic vessels regulate brain tumor drainage and immunity[J]. Cell Res, 2020, 30(3):229-243. DOI: 10.1038/s41422-020-0287-8.
[9] Yamada K, Iwatsubo T. Involvement of the glymphatic/meningeal lymphatic system in Alzheimer's disease: insights into proteostasis and future directions[J]. Cell Mol Life Sci, 2024, 81(1):192. DOI: 10.1007/s00018-024-05225-z.
[10]Salvador AFM, Abduljawad N, Kipnis J. Meningeal lymphatics in central nervous system diseases[J]. Annu Rev Neurosci, 2024, 47(1):323-344. DOI: 10.1146/annurev-neuro-113023-103045.
[11] Chachaj A, Gąsiorowski K, Szuba A, et al. The lymphatic system in the brain clearance mechanisms - new therapeutic perspectives for Alzheimer's disease[J]. Curr Neuropharmacol, 2023, 21(2):380-391. DOI: 10.2174/1570159X20666220411091332.
[12]Louveau A, Herz J, Alme MN, et al. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature[J]. Nat Neurosci, 2018, 21(10):1380-1391. DOI: 10.1038/s41593-018-0227-9.
[13] Da Mesquita S, Louveau A, Vaccari A, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease[J]. Nature, 2018, 560(7717):185-191. DOI: 10.1038/s41586-018-0368-8.
[14] Ye C, Wang S, Niu L, Yang F, et al. Unlocking potential of oxytocin: improving intracranial lymphatic drainage for Alzheimer's disease treatment[J]. Theranostics, 2024, 14(11):4331-4351. DOI: 10.7150/thno.98587.
[15] Shan X, Lu Y, Luo Z, et al. A long-acting lyotropic liquid crystalline implant promotes the drainage of macromolecules by brain-related lymphatic system in treating aged Alzheimer's disease[J]. ACS Nano, 2024, 18(13):9688-9703. DOI: 10.1021/acsnano.4c01206.
[16] Wang L, Zhang Y, Zhao Y, et al. Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice[J]. Brain Pathol, 2019, 29(2):176-192 DOI: 10.1111/bpa.12656.
[17] Hong JP, Chen WF, Nguyen DH, et al. A proposed role for lymphatic supermicrosurgery in the management of Alzheimer's disease: a primer for reconstructive microsurgeons[J]. Arch Plast Surg, 2025,52(2):96-103. DOI:10.1055/a-2513-4313.