Recent advances in anatomy of central nervous lymphatic system and the relationship between it and nervous system diseases

doi:10.13418/j.issn.1001-165x.2025.2.07

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Chinese Journal of Clinical Anatomy ›› 2025, Vol. 43 ›› Issue (2) : 151-156. DOI: 10.13418/j.issn.1001-165x.2025.2.07

Recent advances in anatomy of central nervous lymphatic system and the relationship between it and nervous system diseases

Fan Yongyan, He Peikun, Li Yanyi, Wang Lijuan, Nie Kun*

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Abstract

Central nervous lymphatic system is an important breakthrough in neuroscience research in recent years. The anatomical structure of central nervous lymphatic system mainly includes glial lymphatic system formed around blood vessel wall of astrocyte foot process, and meningeal lymphatic vessels associated with meningeal venous sinus, which have metabolic waste clearance, immune function, signal transduction, material transport and drug delivery, and are regulated by AQP4, hemodynamics, sleep, and circadian rhythm and other factors. At the same time, the system is closely related to neurodegenerative diseases, central nervous system demyelinating diseases, cerebrovascular diseases, and other neurological diseases. This review focuses on anatomical structure, function, and role of nervous system diseases, and summarizes the research progress in recent years.

Key words

Central nervous lymphatic system; / / Glial lymphatic system; / / Meningeal lymphatic vessels; / / Nervous system diseases

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Fan Yongyan, He Peikun, Li Yanyi, Wang Lijuan, Nie Kun. Recent advances in anatomy of central nervous lymphatic system and the relationship between it and nervous system diseases[J]. Chinese Journal of Clinical Anatomy. 2025, 43(2): 151-156 https://doi.org/10.13418/j.issn.1001-165x.2025.2.07

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