Objective To provide new imaging diagnostic basis for the early quantitative diagnosis of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Twenty normal neonates with check of different ages and 40 neonates with HIE of different degrees were selected by arterial spin labeling (ASL) perfusion weighted imaging examination. At the image post-processing workstation, the regions of interest (ROI) of brain structure were divided, and the cerebral blood flow (CBF) value of ROI were measured. The CBF values of brain structure ROI among the different ages and its corresponding ROI in HIE were compared. Results There were statistical significance in the head of caudate nucleus, lenticular nucleus, dorsal thalamus, frontal white matter and the CBF values of ROI in different age groups (P<0.05). The CBF value increased gradually with the increasing of birth age, and the CBF value of the brain nucleus was significantly higher than that of frontal white matter. The CBF values of the head of caudate nucleus, lenticular nucleus, dorsal thalamus and frontal white matter in the observation group were (30.75±1.05) mL/100g·min, (32.02±0.97) mL/100g·min, (39.13±1.36) mL/100g·min, (15.89±0.89) mL/100g·min respectively. There were statistical significances in the CBF value of ROI among the observation group and the mild, moderate, severe lesions groups (P<0.05). The CBF value of the head of caudate nucleus, lenticular nucleus and dorsal thalamus increased gradually with the severity of the disease, while the CBF value of the frontal white matter decreased gradually with the severity of the disease. Conclusions The basal ganglia and dorsal thalamus are the most sensitive parts in the neonatal brain structure to ischemia and hypoxia, the CBF value of ASL perfusion weighted imaging can reflect the level of reperfusion and the degree of injury in the brain structure of HIE in early stage.
Key words
Brain structure; /
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Arterial spin labeled perfusion weighted imaging; /
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Neonate; /
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Cerebral blood flow value; /
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Hypoxic-ischemic encephalopathy
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