中晚期孕期束缚应激对子代下丘脑多巴胺能神经元发育的影响

Abstract

Abstract:

Objective　To investigate the effect of prenatal stress on the development of dopaminergic neurons in hypothalamus of rat offspring.　Methods　Restraint stress was performed three times each day for pregnant SD rats from embryonic day 12-19 in prenatal stress group. The day that the offspring was born was defined as the postnatal day 1. Dopamine expression in the hypothalamus of offspring was observed using the method of immunostaining on postnatal day 1, 7 and 30, respectively.　Results　Body weight of offspring rats in prenatal stress group significantly decreased, while the pixel intensity and level of dopamine in hypothalamus was up-regulated, compared with control group at the postnatal day 1(P<0.05). This change disappeared at the postnatal day 7 and 30.　Conclusions　Prenatal stress had an effect on the prenatal development of dopaminergic neurons in the hypothalamus, which may induce the long-term detrimental consequences for brain function.

Key words: Prenatal stress, Offspring, Hypothalamus, Dopaminergic neurons

CLC Number:

R715.3
R324

HAO Pan-Li, CHEN Yang-Hua, DONG Wei-Ren. Effects of prenatal stress on the development of dopaminergic neurons in the hypothalamus of offspring[J]. Chinese Journal Of Clinical Anatomy, 2012, 30(6): 663-666.

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Effects of prenatal stress on the development of dopaminergic neurons in the hypothalamus of offspring

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