大鼠颈椎骨折错位致脊髓损伤模型的继发性损伤研究

Abstract

Abstract:

Objective To establish a model of secondary SCI of cervical fracture dislocation in rats. Methods 11 male rats were randomly assigned into the cervical fractured islocation group (n=11), the sham group (n=6)。Rats in the experiment group was subjected to fracture dislocation of 1.65 mm at C4/5 at speed of 200 mm/sec, and then stabilized 8 weeks with a custom designed cervical spinal fixation. Behavior was evaluated using the forelimb locomotor and grooming tests. Histology examination was conducted at the lesion epicenter using HE stain. Results The behavior scores of the experiment group were both lower than the sham group. There was rupture of grey mater, cavity in the cord and the cord shrink in the experiment group at 8 weeks after injury. The spared area of the cord at epicenter was (2.79±0.98)mm2 in the experiment group, and lower than the area in the sham group (6.36±0.08) mm2 (P=0.034). Conclusions The present study established the secondary SCI of cervical fracture dislocation in rats. The injury was characterized with the cord damage and locomotor function impair.

Key words: Secondary spinal cord injury, Cervical spine, Dislocation fracture, Rat model

CLC Number:

R744

JIANG Jie, DING Yin, ZHOU Jian, HUANG Zhi-Beng, TUN Xiu-Hua, CHEN Jian-Ting, SHU Jing-An. Secondary spinal cord injury of cervical spine fracturedislocation in rats[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(2): 165-169.

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Secondary spinal cord injury of cervical spine fracturedislocation in rats

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