不同剂量可卡因对昆明小鼠成瘾行为学的影响

Chinese Journal Of Clinical Anatomy ›› 2013, Vol. 31 ›› Issue (3): 325-327.

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Various effect of dose-dependent cocaine on the addicted behavior of KM mice

CHEN Zhen-zhong¹, GU Jing-jing¹, LI Juan¹, ZHANG Lei², CUI Meng-qing³，LI Liang-ping⁴, ZHANG Lu¹

1.Department of Pathphysiology and Key Laboratory of Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China; 2.Department of Histology and embryology, Southern Medical University, Guangzhou 510515, China; 3.Outpatient Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 4.Neurosurgery department of Guangzhou Red Cross Hospital, Guangzhou 510220

Received:2013-04-01 Online:2013-05-25 Published:2013-06-06

Abstract

Abstract:

Objective　To investigate the sensitivity of Kunming mice to different doses of cocaine, and provide reference for the cocaine related research of Kunming mice.　Methods　Kunming mice, male, aged 8~12 weeks, were used. They were randomly divided into two groups. One group was injected with 10 mg/kg cocaine, while the other 20 mg/kg cocaine. Conditioned place preference and Behavior sensitization were used to measure the behavioral differences before and after cocaine treatment.　Results　In the conditioned place preference analysis, the time difference in the white box on day 9 and day 2 (post-pre) was statistically significant（P<0.05） between the two groups. In the Behavior sensitization test, the ambulatory accounts between the two groups were found to be statistically significant（P<0.001）during the time treated with cocaine. And then they were put back to the colony room for 1 week before they received a challenging dose of cocaine. On the challenging day, the ambulatory accounts were found to be statistically significant between them (P=0.001).　Conclusion　Kunming mice can produce more obvious conditioned place preference and more intense behavioral sensitization reaction when treated with 20 mg/kg cocaine.

Key words: KM mice, Dose, Conditioned place preference, Behavioral sensitization

CLC Number:

R338

CHEN Zhen-Zhong, GU Jing-Jing, LI Juan, ZHANG Lei, CUI Meng-Qing, LI Liang-Beng, ZHANG Lu. Various effect of dose-dependent cocaine on the addicted behavior of KM mice[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(3): 325-327.

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Various effect of dose-dependent cocaine on the addicted behavior of KM mice

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