Chinese Journal Of Clinical Anatomy ›› 2013, Vol. 31 ›› Issue (5): 555-559.

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Effects of ginsenoside Rg1 on cell death model in brain tissue after cerebral ischemia-reperfusion  in  rats

YU Li1, LIU Xia1, BAO Cui-fen2, JI Hong-chao1   

  1. 1. Department of Histology and Embryology, 2.Centre of Scientific Expreiment, Liaoning Medical College, Jinzhou 121001,China
  • Received:2012-10-11 Online:2013-09-25 Published:2013-10-16

Abstract:

Objective To study the mechanism of ginsenoside Rg1 after cerebral ischemia-reperfusion in adult rats.    Methods Rats were randomly divided into the sham-operative group(sham group), Model group, ginsenoside Rg1 10、20、40 mg/kg groups, Nimodipine group(drug control group). Cerebral ischemia-reperfusion(CIR) model was made by occluding the middle cerebral artery in rats. After CIR, the neurological deficit score was evaluated and IHC and Western blot technique was used to observe the expressions of PARP-1 and caspase-3. Results   Compared with Model group, the neurological deficit scores and the expressions of PARP-1 and caspase-3 were significantly decreased.  Conclusion   Ginsenoside Rg1 can protect the brain cells from damage after CIR injury by down-regulating  the expression of PARP-1 and caspase-3.

Key words: Ginsenoside Rg1, Cerebral ischemia-reperfusion, Poly ADP-ribose polymerase-1, Caspase-3

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