大鼠脑出血后神经元线粒体的体视学分析及黄芪的神经保护作用研究

Abstract

Abstract:

Objective　To study the protective effect of astragalus to the ultrastructure of apoptotic neurons which surround the intracerebral hemorrhage (ICH). 　Methods　ICH model was established by injecting collagenase Ⅶ into the brain of rats. Method of Narrow-alley Test was applied to study behavioral index. The ultrastructure of neurons around the intracerebral hemorrhage in rats was observed by transmission electron microscope and a stereology analysis was performed on the mitochondria.　Results　mpared with model group, stereology analysis of nerve mitochondria, volume density, numerical density, specific surface and specific membrane of the astragalus treatment group increased notably(P＜0.05). Conclusion Astragalus could protect neurons located near the hemorrhage brain area and abate the neuronal apoptosis with this efficacy better at an early stage following hemorrhage.

Key words: Intracerebral hemorrhage, Astragalus injection, Stereology, Mitochondrion, Rat

CLC Number:

R285.5

WANG De-Ke, ZHANG Hai-Yu, LIU Hai-Xiang, QIN Yi. Analyses on stereology of mitochondrion of neurons that surround intracerebral hemorrhage in rats and the neuroprotective effect of astragalus injection for intracerebral hemorrhage[J]. Chinese Journal Of Clinical Anatomy, 2013, 31(6): 692-695.

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Analyses on stereology of mitochondrion of neurons that surround intracerebral hemorrhage in rats and the neuroprotective effect of astragalus injection for intracerebral hemorrhage

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