Abstract:

Objective　To investigate varying pattern of distribution of gamma aminobutyric acid A receptor (GABAAR) before and after treatment in the brain cortex, striatum, substantianigra on Parkinson's disease.   Methodes　First, the rat model of PD was made, after testing, were randomly divided into treatment group and control group. They were given normal saline and L-dopa methyl ester + Benserazide for 4 weeks. After treatment the behavioral tests were performed. Cerebral cortex, striatum, substantianigra were harvested from rats after treatment of 4, 8, 12 weeks respectively. By immunohistochemistry, the changes in distribution and expression of  content of GABAAR in the brain were compared before and after treatment.　Results　After treatment of 4, 8, 12 weeks immunohistochemical results was subjected through statistical analysis, which showed the content of the brain substantianigra and cortex GABAAR was decreased than before treatment, While the number of striatum showed no changes of GABAAR.　Conclusion　(1) With treatment of L-dopa methyl ester + Benserazide, the PD symptoms can be improve. (2) The changes of GABAAR are different on different parts of PD rats before and after treatment.

Key words: Parkinson's disease, Gamma aminobutyric acid, Gamma aminobutyric acid A receptor