糖尿病大鼠的骨膜反应及染料木素的保护作用

doi:10.13418/j.issn.1001-165x.2016.01.019

Abstract

Abstract:

Objective　To study the changes of the periosteal reaction of the diabetic rat and the protection of genistein. 　Methods　The diabetic model (STZ) of rat was established and randomly divided into a normal group and adiabetic group, with 10 rats in each group； GenLow group； GenHigh group. 20 rats each group. The change of collagen fiber depositing was observed by Van Gieson collagen fiber staining method and the microvascular density was measured by ink infusion method. Results The thickness of periosteum wasreduced in the 10-week diabetic group than those in the control group(P<0.01), the microvascular density and permeability were enlarged. Thickness of periosteum was reduced by GenLow and by GenHigh after 10 weeks of treatment (P<0.01).　Conclusions　With periosteal reaction include periosteal edema, proliferation and regression in the diabetic. Gen could protect the periosteum in the diabetes rats.

Key words: Diabetes, Periosteum, Periosteal reaction, Genistein, Osteogenitor cell, Collagen, Microvesses, Infusion with ink

References

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Changes of the periosteal reaction of diabetic rat and the protection of genistein

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