脊髓损伤后5-HT2A受体的变化与鼠尾痉挛关系的分析

doi:10.13418/j.issn.1001-165x.2016.01.021

Abstract

Abstract:

Objective　To study the relationship between the immunoreactive changes of 5-HT2A receptor and tail Spasticity, within spinal L1 segment after SCI, and to provide a theoretical basis for The treatment of spinal cord injury.　Methods　Sixty adult males Wistar rats were randomly separated into three groups: control group, attacked group and transversed group. To study 5-HT2AR immunoreactivity and hyperexcitability of tail of rats. Results (1) Compared the attacked and transversed groups with the control group, 5-HT2AR-IR density significantly increased in both attacked and transversed groups compared with that in the control group. (2) Spasticity and reflective hyperfunction symptom after SCI were positively correlated with 5-HT2AR-IR density and extent of SCI. Conclusion Spasticity and reflective hyperfunction symptom after SCI are positively correlated wtih 5-HT2AR-IR density and the extent of SCI, which provides the theoretical basis for using 5-HT2A receptor blockers in patients with limb spasm.

Key words: Spinal cord injury, 5-HT2A receptor, Spasticity

References

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Analysis of the relationship between the changes of 5-HT2A receptor in spinal cord and the mouse tail spasm after spinal cord injury

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