含硫氨基酸对糖尿病大鼠窦房结损伤的保护作用

doi:10.13418/j.issn.1001-165x.2017.06.014

Chinese Journal Of Clinical Anatomy ›› 2017, Vol. 35 ›› Issue (6): 661-664.doi: 10.13418/j.issn.1001-165x.2017.06.014

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Protective role of sulphur-containing amino acids on sinoatrial node dysfunction in type 1 diabetes rat model

ZHOU Li¹, WANG Qing-zhi², WANG Zhi-yong¹

1. Department of Anatomy, 2.Department of Forensic Medicine, Xinxiang Medical University, Xinxiang 453003, China

Received:2017-09-08 Online:2017-11-25 Published:2017-12-30

Abstract

Abstract:

Objective　To explore the effects of cysteine or taurine on sinoatrial node dysfunction in diabetic rats and the underlying mechanism.　Methods　SD rats were randomly divided into four groups:control group(C) diabetes mellits group(DM), diabetes mellits+cysteine group(DM+Cys), diabetes mellits+taurine group(DM+Tau). The blood content of SOD and MDA were assessed. The sinoatrial node function was detected by SNRT, CSNRT, SACT and IHR. We also measured the expression of SOD2, HO-1, Nox2, Nox4, HCN2 and HCN4.　Results 　Compared with C group, the levels of SOD decreased, whereas MDA increased in DM group. The IHR was reduced with the prolonging of SNRT, CSNRT and SACT. The DM group exhibited down-regulated expression of SOD2, HO-1, HCN2 and HCN4 but up-regulated expression of NOX2 and NOX4 (P<0.05). Compared with DM group, DM+Cys and DM+Tau group showed increased SOD, prolonged IHR, up-regulated expression of SOD2, HO-1, HCN2 and HCN4, down-regulated expression of NOX2 and NOX4 (P<0.05). 　Conclusion　Cysteine or taurine supplementation can reduce the oxidative stress, increased the expression of HCN2 and HCN4, improve the sinoatrial node dysfunction in diabetic rats.

Key words: Cysteine, 　Taurine, 　Sinoatrial node, 　Diabetes mellits

ZHOU Li, WANG Qing-zhi, WANG Zhi-yong. Protective role of sulphur-containing amino acids on sinoatrial node dysfunction in type 1 diabetes rat model[J]. Chinese Journal Of Clinical Anatomy, 2017, 35(6): 661-664.

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Protective role of sulphur-containing amino acids on sinoatrial node dysfunction in type 1 diabetes rat model

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