Abstract: Objective　To investigate the clinical effect of recombinant human bone morphogenetic protein 2(CPC/rhBMP-2)-loaded calcium phosphate cement scaffold combined with autogenous bone graft in the treatment of non-infectious atrophy type limbs nonunion.　Methods　A total of 16 patients (12 males, 4 females; aged from 16ys to 67ys, mean age: 37.06±16.31 ys) with limbs nonunion after surgical treatment of fractures from September 2013 to September  2017 were analyzed retrospectively. Bone nonunion part were  lower limbs (tibia 5 cases, femur 3 cases, calcaneus 1 case, fibula 1 case) and upper limbs (radius 3 cases, clavicle 1 case, scaphoid 1 case). All patients were treated with CPC/rhBMP-2 scaffold combined with autogenous bone grafting in the center of bone defect. Follow-up patients were treated with X-ray to observe the fractures healing after operation and record the complication till fractures healed. Upper extremity dysfunction assessment scale (DASH), lower extremity function scale (LEFS) and SF-12 quality of life scale were used to evaluate the effect pre- and post-treatment.　Results　Mean follow-up period was 16.93±4.06 months (ranged from 12 to 26 months). X-ray film showed that all fractures were healed, healing time was 3~10 months (mean 5.43±2.25 months). There were statistical difference between preoperative and postoperative DASH, LEFS and SF-12 scale (P<0.05).　Conclusions　CPC/rhBMP-2 combined with autogenous bone graft are effective and safe in the treatment of non-infectious atrophy type limbs nonunion.

Key words: Autogenous bone grafting,  ,  , Atrophic nonunion, 　Osteoinductive membrane,  ,  , Calcium phosphate,  ,  , Bone morphogenetic protein