Abstract: Objective　To explore the clinical application value of digital biliary system in minimally invasive surgery for complex gallstone disease.　Methods　41 patients with complex cholelithiasis were selected from April 2018 to July 2019. They were randomly divided into an experimental group and a control group. In the experimental group, the hepatobiliary model which established by their CT data was introduced to the digital biliary tract system, and then were applied in preoperative evaluation, surgical simulation, and lithotripsy extraction plan for intraoperative guidance. Minimally invasive surgery was performed on the two groups. Reexamination of stones and recurrence were detected by ultrasound or CT.　Results　The biliary tract and stones in the experimental group were consistent with those in the digital biliary system. The actual surgical method was consistent with the preoperative simulation and planning. The mean operation time was (160.10 ± 78.82) min, the intraoperative bleeding volume was (2.95±2.28) ml, and the intestinal recovery time was (1.13±0.70) days, all were less than those in the control group. No severe perioperative complications, residual stones and recurrence occurred. In the control group, there were 2 cases of residual stones, 1 case of gastrointestinal bleeding, and 2 cases of recurrence of stones.　Conclusions　The digital biliary system showed good guiding significance and application value for minimally invasive surgery for complex cholelithiasis. It could decrease the operation time and intraoperative bleeding and shorten intestinal recovery time and would be safe and efficient.

Key words: Digital biliary system, 　Cholelithiasis, 　Intraoperative navigation, 　Precise treatment