基于柠檬酸合成的新型可降解螺钉生物相容性和生物力学特性的研究

doi:10.13418/j.issn.1001-165x.2021.02.012

Abstract

Abstract: weighing, 8-11 kg) were selected to prepare the models (AO classification type: B1) of bilateral lateral femoral condyle fracture. Right fracture was fixed with POC-click-HA absorbable cannulated screws as an experimental group and left fracture with Poly-DL-Lactic acid(PDLLA) screws as a control group. At 4, 8, and 12 weeks after operation, general observation was done, Lane - Sandhu histologic grading, biomechanics were taken for observing fracture healing.　Results　All aniamls survived to the end of the experiment. General observations showed that no fracture displacement occurred and fracture healed at 12 weeks in the two groups. POC - click - HA screws degraded and new bone tissue was found from samples at 12 weeks. According to the Lane - Sandhu histologic grading, , there was no statistical difference between two groups in the screws at 4, 8, and 12 weeks after operation (P>0.05). Biomechanics test showed that the maximum load at the nail-bone interface of the POC-click-HA group was lower than that of the PDLLA group at 4 weeks after operation (P<0.05). While there was no significant difference between the two groups at 8 weeks and 12 weeks (P>0.05). 　Conclusions　Citric acid polymer composite hydroxyapatite (POC-click-HA) screw has good biocompatibility and biomechanics,which can be better utilized for Beagles’ lateral femoral condyle B1 fractures.

Key words: Biodegradable bone screws;　Lateral femoral epicondyle fracture;　Citric acid; , Biocompatibility;　Biomechanics

CLC Number:

R318.08

Yang Cheng , Li Zhen, Liao Jianwen, Fan Shicai, Yang Jian, Bai Xiaochun. Research on the biocompatibility and biomechanics of citrate-based biodegradable screws [J]. Chinese Journal of Clinical Anatomy, 2021, 39(2): 182-186.

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Research on the biocompatibility and biomechanics of citrate-based biodegradable screws

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