厄贝沙坦对高血压合并2型糖尿病大鼠胰岛素抵抗IRS-1/PI3K/GLUT4信号通路的影响

doi:10.13418/j.issn.1001-165x.2021.05.012

Abstract

Abstract: Objective To investigate the effect of irbesartan on insulin resistance in hypertensive rats with type 2 diabetes mellitus (T2DM). Methods Spontaneously hypertensive rats (SHR) were randomly divided into a model group, an irbesartan low dose group and an irbesartan high dose group. Normal rats were used as control group. Irbesartan was administered daily at 30 and 60 mg/kg in the low and high dose groups, while the same amount of normal saline was performed in the control group and model group. Systolic blood pressure (SBP), fasting blood glucose (FBG), insulin resistance model evaluation index (HOMA-IR), insulin receptor substrate -1 (IRS-1), phosphatidylinositol (-3) kinase P85 subunit (PI3Kp85), protein kinase B (AKT), phosphorylated protein (p-AKT), and glucose transporter 4 (GLUT4) were measured in rats. Results Compared with the control group, SBP, FBG, FINS and HOMA-IR in the model group significantly increased (P<0.05), while IRS-1, PI3Kp85, P-Akt and GLUT4 significantly decreased (P<0.05). Compared with the model group, the above indicators were reversed in both the low and high dose irbesartan groups(P<0.05). Conclusions Irbesartan can improve insulin resistance in T2DM rats with hypertension through IRS-1/PI3K/GLUT4 signaling pathway.

Key words: Irbesartan, High blood pressure; , , Type 2 diabetes; , , Insulin resistance; , , IRS-1/PI3K/GLUT4 signaling pathway

CLC Number:

Liu Li, Luo Peng, Zhou Tiantian, Li Yan, Xie Hongyan, Lv De. Effect of irbesartan on insulin resistance IRS-1/PI3K/GLUT4 signaling pathway in rats with hypertension and type 2 diabetes mellitus[J]. Chinese Journal of Clinical Anatomy, 2021, 39(5): 563-568.

References 15

[1]	Han YJ, Nie LH, Ye XH, et al. The association between Toxoplasma gondii infection and hypertensive disorders in T2DM patients: a case-control study in the Han Chinese population[J]. Parasitology Research, 2018, 117(3): 689-695. DOI: 10.1007/s00436-017-5737-y.
[2]	Batchuluun B, Rijjal DA, Prentice KJ, et al. Elevated medium-chain acylcarnitines are associated with gestational diabetes mellitus and early progression to type 2 diabetes and induce pancreatic β-cell dysfunction[J]. Diabetes, 2018, 67(5): 885-897. DOI: 10.2337/db17-1150.
[3]	Yee HY, 杨晶晶, 万毅刚, 等. 胰岛素抵抗的分子机制及中药的干预作用[J]. 中国中药杂志, 2019, 44(7): 1289-1294. DOI: 10.19540/j.cnki.cjcmm.20181105.003.
[4]	Koska J, Lopez L, D'souza K, et al. Effect of liraglutide on dietary lipid-induced insulin resistance in humans[J]. Diabetes Obes Metab, 2018, 20(1): 69-76. DOI: 10.1111/dom.13037.
[5]	万鹤鸣, 王卓, 陆守荣, 等. 厄贝沙坦对颈动脉粥样硬化合并2型糖尿病患者高敏C反应蛋白和胰岛素抵抗指数的影响[J]. 新乡医学院学报, 2012, 29(1): 53-55. DOI: CNKI: SUN:XXYX.0.2012-01-016.
[6]	Wong WY, Ward LC, Fong CW, et al. Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats[J]. Eur J Nutr, 2017, 56(1): 133-150. DOI: 10.1007/s00394-015-1064-1.
[7]	陈碧珊, 吴红卫, 李艳, 等. 厄贝沙坦对糖尿病大鼠肾脏FN、DKK1及β-catenin表达的影响[J]. 山东医药, 2018, 58(32): 47-50. DOI: 10.3969/j.issn.1002-266X.2018.32.012.
[8]	Wefers J, van Moorsel D, Hansen J, et al. Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle[J]. Proc Natl Acad Sci U S A, 2018, 115(30): 7789-7794. DOI: 10.1073/pnas.1722295115.
[9]	Li Z, Zhu Y, Li C, et al. Liraglutide ameliorates palmitate-induced insulin resistance through inhibiting the IRS-1 serine phosphorylation in mouse skeletal muscle cells[J]. J Endocrinol Invest, 2018, 41(9): 1097-1102. DOI: 10.1007/s40618-018-0836-x.
[10]	Kostis JB, Vachharajani NN, Hadjilambris OW, et al. The pharmacokinetics and pharmacodynamics of irbesartan in heart failure[J]. J Clin Pharmacol, 2001, 41(9): 935-942. DOI: 10.1177/009127 00122010906.
[11]	Gu ZX, Mu H, Shen HH, et al. High level of dietary soybean oil affects the glucose and lipid metabolism in large yellow croaker Larimichthys crocea through the insulin-mediated PI3K/AKT signaling pathway[J]. Comp Biochem Physiol B Biochem Mol Biol, 2019, 231: 34-41. DOI: 10.1016/j.cbpb.2018.12.003.
[12]	Wang KP, Wang HX, Liu YG, et al. Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism[J]. Journal of Functional Foods, 2018, 40: 261-271. DOI: 10.1016/j.jff.2017.11.004.
[13]	Ren LY, Zhou X, Huang XQ, et al. The IRS/PI3K/Akt signaling pathway mediates olanzapine-induced hepatic insulin resistance in male rats[J]. Life Sci, 2019, 217: 229-236. DOI: 10.1016/j.lfs.2018.12.015.
[14]	舒畅, 范强, 杨丽霞，等. 昆仑雪菊提取物对糖尿病大鼠胰岛素抵抗IRS-1/PI3K/GLUT4信号通路的影响[J]. 中国实验方剂学杂志, 2017, 23(11): 122-127. DOI: 10.13422/j.cnki.syfjx.2017110122.
[15]	Abdelmageed ME, Shehatou GS, Abdelsalam RA, et al. Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction[J]. Naunyn-Schmiedebergs Arch Pharmacol, 2019, 392(2): 243-258. DOI: 10.1007/s00210-018-1583-4.

Effect of irbesartan on insulin resistance IRS-1/PI3K/GLUT4 signaling pathway in rats with hypertension and type 2 diabetes mellitus

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