少阳生骨方对SD大鼠胫骨骨折断端18F-NaF分布的影响

doi:10.13418/j.issn.1001-165x.2018.05.013

Abstract

Abstract:

Objective　To explore the application value of 18F-NaF in evaluation of early fracture healing, and the effects of ShaoYangShengGuFang Prescription on rat fracture healing.　Methods　72 SD rats were performed left tibial fracture modeling. The model rats were randomly divided into experimental group (intragastric administration of ShaoYangShengGuFang Prescription)，control group (intragastric administration of Ossotide Tablets) and blank group (intragastric administration of 0.9% saline). Every group included 24 rats. After 7, 15, 30, and 56 days, 6 rats were randomly selected from each of the three groups. The PET/CT scan was performed on the fractured ends of tibial fractures, and the uptake of 18F-NaF at the fracture end was calculated.　Results　The 18F-NaF uptake of experimental group and control group reached their peaks at the 15th day (9.00±0.42 %ID/g、8.10±0.71 %ID/g), while the 18F-NaF uptake of blank group reached its peak at the 30th day (4.25±0.35 %ID/g). At four different time points, there was no significant difference between the uptake of the experimental group and that of the control group in the 18F-NaF uptake of rat tibial fracture bone (P>0.05), while the 18F-NaF uptake of the experimental group or the control group was higher than that of the blank group, which was of remarkable statistical difference (P<0.05). Conclution　18F-NaF has some values in evaluating early fracture healing, and ShaoYangShengGuFang Prescription can promote the healing of tibial fractures in rats.

Key words: ShaoYangShengGuFang Prescription, 　18F-sodium fluoride, 　PET/CT, 　Fracture healing, 　Rat

GUO Xiao-guang, GUAN Tai-yuan, ZHANG Lei, FU Shi-jie, ZHOU Xin, LIU Gang, CHEN Yue. Effects of ShaoYangShengGuFang Prescription on the distribution of 18F-NaF in rat tibial fracture bone[J]. Chinese Journal Of Clinical Anatomy, 2018, 36(5): 545-550.

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Effects of ShaoYangShengGuFang Prescription on the distribution of 18F-NaF in rat tibial fracture bone

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