乳腺癌中跨膜蛋白81基因高表达不利于患者预后

doi:10.13418/j.issn.1001-165x.2018.05.021

Abstract

Abstract:

Objective　To investigate the expression of transmembrane protein 81 (TMEM81) in breast cancer and its correlation with the prognosis of breast cancer. Methods　The cBioPortal, UALCAN, and the cancer multi-omics and clinical database LinkedOmics were used to analyze changes of TMEM81 gene in breast cancer and its relationship with clinical prognosis. 　Results　Analysis by cBioPortal showed that TMEM81 gene was changed in 26% invasive breast cancer patients including mutation, copy number alteration and mRNA up-regulation, in which 18% patients’ TMEM81 mRNA level was higher than default threshold (EXP≥2). Besides, up-regulation of TMEM81 mRNA was bad for prognosis (P<0.05). Results From UALCAN showed that level of TMEM81 mRNA increased significantly in invasive breast cancer tissues compared with normal breast tissues (P<0.01). Results from LinkedOmics showed that TMEM81 expression was significantly affected by PAM50, ER, PR, pathologic stage, pathology T stage, histological type, race and age respectively (P<0.01, P<0.01, P<0.01, P<0.01,P<0.01, P<0.05, P<0.01, P<0.05). TMEM81 mRNA level was positively correlated with its gene copy-number alteration (P<0.01), and was negatively correlated with its DNA methylation (P<0.01). Conclusion　The alteration of gene copy number and the level of DNA methylation promote the expression of TMEM81 , the higher level of its mRNA is, the worse it is for prognosis, beyond that TMEM81 could become a candidate marker for prognosis of breast cancer.

Key words: Breast cancer, Transmembrane Protein 81;　Prognosis;　Copy number alteration;　DNA methylation

ZHANG Hu, DU Xin-na, ZHUANG Ying, SUN Hai-yan, FAN Wei-ping, ZHAO Xiao-fang. High expression of transmembrane protein 81 is bad for prognosis of breast cancer patients[J]. Chinese Journal Of Clinical Anatomy, 2018, 36(5): 586-589.

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High expression of transmembrane protein 81 is bad for prognosis of breast cancer patients

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