葛根素对臂丛根性撕脱后脊髓MMP-9蛋白表达的影响

doi:10.13418/j.issn.1001-165x.2019.02.007

Abstract

Abstract:

Objective To investigate the expression changes of matrix metalloproteinase-9 (MMP-9) in spinal cord after brachial plexus root avulsion and the effect of Puerarin on its expression. Methods A total of 174 adult male SD rats were randomly divided into a normal group, a model group, Puerarin low, medium and high treatment groups. The model group and the Puerarin treatment groups underwent the right C5~C7 anterior nerve root avulsion. The rats were injected intraperitoneally Puerarin every day after the operation. The expression of MMP-9 protein in C5~C7 segment of spinal cord was detected by Western Blot. Results Compared with the normal group, the expression of MMP-9 protein peaked at the 1st day after brachial plexus root avulsion, decreased near to normal at the 3rd day and decreased to a lower level after 1 week. The expression of MMP-9 protein in spinal cord tissue of Puerarin treatment group was significantly lower than the model group at the 1st day. Conclusion MMP-9 may be involved in the early injury response to brachial plexus root avulsion, and Puerarin may help to alleviate this injury.

Key words: Puerarin, 　Brachial plexus, 　Nerve injury, 　Matrix metalloproteinase-9

CHEN Chuan-qi, CHEN Long-ju, WU Tai-ding, TAN Yun-xia, LI Dan, WANG Yu . Effect of Puerarin on the expression of MMP-9 protein in spinal cord after brachial plexus root avulsion[J]. Chinese Journal Of Clinical Anatomy, 2019, 37(2): 148-152.

References 23

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Effect of Puerarin on the expression of MMP-9 protein in spinal cord after brachial plexus root avulsion

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