卵巢癌中ETV4基因高表达对患者预后的临床意义

doi:10.13418/j.issn.1001-165x.2019.02.021

Abstract

Abstract:

Objective　To investigate the correlation of the high expression of ETS Translocation Variant(ETV4) gene with prognosis of patients with ovarian cancer. Methods　The expression levels of ETV4 gene in normal human tissue and ovarian cancer tissue, and patients survival were analyzed using the BioGPS database, Oncomine database, Encyclopedia(CCLE) and Kaplan-Meier Plotter database. The relationship between the gene mutation of ETV4 in ovarian cancer and prognosis of patients was analyzed using the cBioPortal database.　Results The analysis results of BioGPS database showed that the expression of ETV4 gene was low in normal ovarian tissue. Among 340 items searched from Oncomine database, 32 items showed that the expression levels of ETV4 increased, and 2 items showed that the expression levels of ETV4 decreased. Meta-analysis of two studies showed that the ETV4 gene was highly expressed in ovarian cancer tissues (P<0.05). CCLE analysis showed that the ETV4 gene was highly expressed in ovarian cancer cells. Kaplan-Meier Plotter database showed that the Overall Survival (OS) and Disease Free Survival (DFS) in ovarian cancer patients with high expression levels of ETV4 gene were significantly prolonged compared with ovarian cancer patients with low expression levels of ETV4 gene (P<0.05). The results of the cBioPortal database showed that the gene mutation rate of ETV4 in ovarian cancer was 2.5%, which had no significant effect on OS and DFS in patients with ovarian cancer (P>0.05).　Conclusions　The ETV4 gene is highly expressed in ovarian cancer tissue, which has a significant prolongation of OS and DFS in patients with ovarian cancer, and can be used as a candidate for assessment of clinical prognosis of patients ovarian cancer. The mutation of ETV4 gene has no significant effects on the OS and DFS of ovarian cancer patients.

Key words: Ovarian Cancer, 　Gene, 　Tumor, 　Survival

YU Peng, YANG Yue, LU Jin,LAI Gui-hua, ZHANG Hao-xuan. The correlation of the high expression of ETV4 gene with prognosis of patients with ovarian cancer[J]. Chinese Journal Of Clinical Anatomy, 2019, 37(2): 217-222.

References 24

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The correlation of the high expression of ETV4 gene with prognosis of patients with ovarian cancer

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