Abstract: 　Objective　To analyze the characteristics of percutaneous vertebroplasty (PVP) bone cement leakage, and to investigate the risk factors of PVP bone cement leakage.　Methods　A total of 111 patients (147 vertebral body) with osteoporotic vertebral compression fractures (osteoporotic vertebral compression fracture, OVCF) who were treated with PVP in our hospital from January 2016 to December 2018 were selected. Preoperative DR, 3D CT and MRI examinations were performed for all vertebral segments with fracture, and postoperative DR or 3D CT reexaminations were performed. The effects of gender, age, vertebral body position and vertebral body injury (fissure sign, cortical bone injury) on the rate of bone cement leakage and the characteristics of bone cement leakage were analyzed.　Results　Gender, age and vertebral body position had no significant effect on the bone cement leakage rate. Vertebral fissure sign combined with cortical injury was related with the highest rate of cement leakage, and cortical injury was related with the highest amount of cement leakage, and the differences were statistically significant (P＜0.001). The incidence of bone cement pervertebral leakage was the highest, followed by intervertebral disc leakage and  intraspinal leakage in sequence. The difference was statistically significant (P=0.005).  Conclusion　Vertebral body injury is an important cause of bone cement leakage in PVP treatment. Careful observation of the imaging characteristics of preoperative vertebral body injury is of great significance in prevention of  bone cement leakage. 

Key words:  , Osteoporosis vertebral compression fracture, Percutaneous vertebroplasty, Vertebral body injury, Bone cement leakage